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2/28/2020 10:02:29 AM | Browse: 71 | Download: 46
Publication Name World Journal of Stem Cells
Manuscript ID 52207
Country/Territory China
Received
2019-10-22 03:54
Peer-Review Started
2019-10-22 03:56
To Make the First Decision
Return for Revision
2019-11-18 19:11
Revised
2019-12-27 07:53
Second Decision
2020-01-18 07:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-01-20 03:28
Articles in Press
2020-01-20 03:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-02-25 01:54
Publish the Manuscript Online
2020-02-27 07:06
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Rehabilitation
Manuscript Type Basic Study
Article Title C-C chemokine receptor type 2-overexpressing exosomes alleviated experimental post-stroke cognitive impairment by enhancing microglia/macrophage M2 polarization
Manuscript Source Invited Manuscript
All Author List Huai-Chun Yang, Min Zhang, Rui Wu, Hai-Qing Zheng, Li-Ying Zhang, Jing Luo, Li-Li Li and Xi-Quan Hu
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81871847
National Natural Science Foundation of China 81672261
Corresponding author Xi-Quan Hu, MD, PhD, Chief Physician, Professor, Department of Rehabilitation Medicine, the Third Affiliated Hospital, Sun Yat-sen University, No. 600 Tianhe road, Guangzhou 510000, Guangdong, China. sysu_hu@163.com
Keywords Cognitive impairment; Stroke; Exosomes; C-C chemokine receptor type 2; Microglia/macrophage polarization; Remyelination
Core Tip Exosomes have been reported to possess the therapeutic benefit comparable to the therapeutic effects of mesenchymal stromal cells. However, the effects of exosomes derived from human umbilical cord mesenchymal stem cells (ExoCtrl) on post-stroke cognitive impairment (PSCI) have rarely been reported. Moreover, whether exosomes derived from C-C chemokine receptor type 2 (CCR2)-overexpressing human umbilical cord mesenchymal stem cells (ExoCCR2) have better therapeutic effects on PSCI and the possible mechanisms underlying these effects remained unclear. This study provides new insights into the use of genetically modified exosomes for PSCI treatment, offering new ideas for the clinical application of exosome-based therapies for PSCI.
Publish Date 2020-02-27 07:06
Citation Yang HC, Zhang M, Wu R, Zheng HQ, Zhang LY, Luo J, Li LL, Hu XQ. C-C chemokine receptor type 2-overexpressing exosomes alleviated experimental post-stroke cognitive impairment by enhancing microglia/macrophage M2 polarization. World J Stem Cells 2020; 12(2): 152-167
Url https://www.wjgnet.com/1948-0210/full/v12/i2/152.htm
DOI https://dx.doi.org/10.4252/wjsc.v12.i2.152
Full Article (PDF) WJSC-12-152.pdf
Full Article (Word) WJSC-12-152.docx
Manuscript File 52207-Review.docx
Answering Reviewers 52207-Answering reviewers.pdf
Audio Core Tip 52207-Audio core tip.m4a
Biostatistics Review Certificate 52207-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 52207-Conflict-of-interest statement.pdf
Copyright License Agreement 52207-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 52207-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 52207-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 52207-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 52207-Language certificate.pdf
Supplementary Material 52207-Supplementary material.pdf
Peer-review Report 52207-Peer-review(s).pdf
Scientific Misconduct Check 52207-Scientific misconduct check.pdf
Scientific Editor Work List 52207-Scientific editor work list.pdf