| Category |
Microbiology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Evaluation of bacterial biomarkers to aid in challenging inflammatory bowel diseases diagnostics and subtype classification
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Mireia Lopez-Siles, Xavier Aldeguer, Miriam Sabat-Mir, Mariona Serra-Pagès, Sylvia H Duncan, Harry J Flint, L Jesús Garcia-Gil and Margarita Martinez-Medina |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Spanish Ministry of Education and Science |
SAF2010-15896 |
| Spanish Ministry of Education and Science |
SAF2013-43284-P |
| Spanish Ministry of Education and Science |
SAF2017-82261-P |
|
| Corresponding Author |
Margarita Martinez-Medina, PhD, Associate Professor, Laboratory of Molecular Microbiology, Biology Department, Universitat de Girona, Carrer de Maria Aurèlia Capmany, 40, Girona 17003, Spain. marga.martinez@udg.edu |
| Key Words |
Crohn’s disease; Ulcerative colitis; Inflammatory bowel disease; Diagnostic tests; Faecalibacterium prausnitzii; Escherichia coli |
| Core Tip |
This manuscript evaluates the usefulness of new indexes calculated from the quantification of Faecalibacterium prausnitzii, its phylogroups, and Escherichia coli as biomarkers to assist in challenges of inflammatory bowel disease diagnostics. Firstly, discrimination between inflammatory bowel disease and other intestinal disorders was tested. We present indices to distinguish colorectal cancer from inflammatory bowel disease, especially from subjects with ulcerative colitis. This is of significance given the association between chronic inflammation and the risk of colorectal cancer. In contrast, the proposed indices featured limited performance for discriminating inflammatory bowel disease from irritable bowel syndrome. Secondly, we approach if these biomarkers would be useful to discriminate within inflammatory bowel disease subtypes. We show here good biomarkers to differentiate inflammatory bowel disease subtypes of shared disease location, which may assist in monitoring the risk of progression of the inflamed area. Their application in non-invasive faecal samples is also demonstrated. |
| Publish Date |
2020-05-12 03:08 |
| Citation |
Lopez-Siles M, Aldeguer X, Sabat-Mir M, Serra-Pagès M, Duncan SH, Flint HJ, Garcia-Gil LJ, Martinez-Medina M. Evaluation of bacterial biomarkers to aid in challenging inflammatory bowel diseases diagnostics and subtype classification. World J Gastrointest Pathophysiol 2020; 11(3): 64-77 |
| URL |
https://www.wjgnet.com/2150-5330/full/v11/i3/64.htm |
| DOI |
https://dx.doi.org/10.4291/wjgp.v11.i3.64 |
