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5/14/2020 8:57:21 AM | Browse: 167 | Download: 116
Publication Name World Journal of Gastroenterology
Manuscript ID 53842
Country/Territory China
Received
2019-12-31 11:19
Peer-Review Started
2019-12-31 11:19
To Make the First Decision
Return for Revision
2020-01-19 18:54
Revised
2020-03-27 04:50
Second Decision
2020-04-16 07:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-04-16 23:08
Articles in Press
2020-04-16 23:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-04-20 14:17
Typeset the Manuscript
2020-05-13 00:17
Publish the Manuscript Online
2020-05-14 03:43
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Folic acid attenuates high-fat diet-induced steatohepatitis via deacetylase SIRT1-dependent restoration of PPARα
Manuscript Source Unsolicited Manuscript
All Author List Feng-Zhi Xin, Ze-Hua Zhao, Rui-Nan Zhang, Qin Pan, Zi-zhen Gong, Chao Sun and Jian-Gao Fan
Funding Agency and Grant Number
Funding Agency Grant Number
National Key R and D Program of China 2017YFC0908903
National Natural Science Foundation of China 81873565
National Natural Science Foundation of China 81470840
National Natural Science Foundation of China 81700503
Corresponding author Jian-Gao Fan, MD, PhD, Chief Doctor, Professor, Center for Fatty Liver, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China. fanjiangao@xinhuamed.com.cn
Key Words Nonalcoholic fatty liver disease; Folic acid; Gut microbiota; PPARα; SIRT1;
Core Tip The role of folic acid in hepatic lipid metabolism, hepatic one-carbon metabolism and gut microbiota in high-fat diet (HFD)-induced steatohepatitis is still unknown. This study confirmed that folic acid ameliorated HFD-induced steatohepatitis by restoring PPARα levels via a SIRT1 dependent mechanism. Moreover, folic acid restored depleted hepatic one-carbon metabolism and the diversity of gut microbiota. All these findings further clarified the improvement effect of folic acid on HFD-induced steatohepatitis and suggested that folic acid may become a therapeutic drug to treat non-alcoholic fatty liver disease in the future.
Publish Date 2020-05-14 03:43
Citation Xin FZ, Zhao ZH, Zhang RN, Pan Q, Gong ZZ, Sun C, Fan JG. Folic acid attenuates high-fat diet-induced steatohepatitis via deacetylase SIRT1-dependent restoration of PPARα. World J Gastroenterol 2020; 26(18): 2203-2220
Url https://www.wjgnet.com/1007-9327/full/v26/i18/2203.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i18.2203
Full Article (PDF) WJG-26-2203.pdf
Full Article (Word) WJG-26-2203.docx
Manuscript File 53842-Review_WangTQ.docx
Answering Reviewers 53842-Answering reviewers.pdf
Audio Core Tip 53842-Audio core tip.m4a
Biostatistics Review Certificate 53842-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 53842-Conflict-of-interest statement.pdf
Copyright License Agreement 53842-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 53842-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 53842-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 53842-Language certificate.pdf
Peer-review Report 53842-Peer-review(s).pdf
Scientific Misconduct Check 53842-Scientific misconduct check.pdf
Scientific Editor Work List 53842-Scientific editor work list.pdf