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5/14/2020 8:57:21 AM | Browse: 577 | Download: 892
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Received |
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2019-12-31 11:19 |
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Peer-Review Started |
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2019-12-31 11:19 |
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To Make the First Decision |
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Return for Revision |
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2020-01-19 18:54 |
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Revised |
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2020-03-27 04:50 |
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Second Decision |
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2020-04-16 07:15 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-04-16 23:08 |
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Articles in Press |
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2020-04-16 23:08 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-04-20 14:17 |
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Typeset the Manuscript |
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2020-05-13 00:17 |
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Publish the Manuscript Online |
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2020-05-14 03:43 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Folic acid attenuates high-fat diet-induced steatohepatitis via deacetylase SIRT1-dependent restoration of PPARα
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Feng-Zhi Xin, Ze-Hua Zhao, Rui-Nan Zhang, Qin Pan, Zi-zhen Gong, Chao Sun and Jian-Gao Fan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key R and D Program of China |
2017YFC0908903 |
| National Natural Science Foundation of China |
81873565 |
| National Natural Science Foundation of China |
81470840 |
| National Natural Science Foundation of China |
81700503 |
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| Corresponding Author |
Jian-Gao Fan, MD, PhD, Chief Doctor, Professor, Center for Fatty Liver, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China. fanjiangao@xinhuamed.com.cn |
| Key Words |
Nonalcoholic fatty liver disease; Folic acid; Gut microbiota; PPARα; SIRT1; |
| Core Tip |
The role of folic acid in hepatic lipid metabolism, hepatic one-carbon metabolism and gut microbiota in high-fat diet (HFD)-induced steatohepatitis is still unknown. This study confirmed that folic acid ameliorated HFD-induced steatohepatitis by restoring PPARα levels via a SIRT1 dependent mechanism. Moreover, folic acid restored depleted hepatic one-carbon metabolism and the diversity of gut microbiota. All these findings further clarified the improvement effect of folic acid on HFD-induced steatohepatitis and suggested that folic acid may become a therapeutic drug to treat non-alcoholic fatty liver disease in the future. |
| Publish Date |
2020-05-14 03:43 |
| Citation |
Xin FZ, Zhao ZH, Zhang RN, Pan Q, Gong ZZ, Sun C, Fan JG. Folic acid attenuates high-fat diet-induced steatohepatitis via deacetylase SIRT1-dependent restoration of PPARα. World J Gastroenterol 2020; 26(18): 2203-2220 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i18/2203.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i18.2203 |
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