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5/28/2020 3:29:31 AM | Browse: 579 | Download: 1419
Publication Name World Journal of Immunology
Manuscript ID 54388
Country/Territory Israel
Received
2020-01-25 21:47
Peer-Review Started
2020-01-25 21:48
To Make the First Decision
Return for Revision
2020-04-19 21:44
Revised
2020-05-09 18:54
Second Decision
2020-05-12 08:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-05-13 06:34
Articles in Press
2020-05-13 06:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-05-18 08:02
Publish the Manuscript Online
2020-05-27 13:47
ISSN 2219-2824 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Immunology
Manuscript Type Editorial
Article Title PICOT promotes T lymphocyte proliferation by down-regulating cyclin D2 expression
Manuscript Source Invited Manuscript
All Author List Pinakin Pandya and Noah Isakov
Funding Agency and Grant Number
Funding Agency Grant Number
USA-Israel Binational Science Foundation 2013034
Israel Science Foundation administered by the Israel Academy of Science 1235/17
Jacki and Bruce Barron Cancer Research Scholars’ Program, City of Hope and the Israel Cancer Research Fund 87735611
Corresponding Author Noah Isakov, PhD, Professor, The Shraga Segal Department of Microbiology, Immunology and Genetics, Faculty of Health Sciences and the Cancer Research Center, Ben Gurion University of the Negev, P.O.B. 653, Beer Sheva 84105, Israel. noah@bgu.ac.il
Key Words Protein kinase C-interacting cousin of thioredoxin; Glutaredoxin 3; Cyclin D2; Histone methylation; T lymphocyte; Histone 3 lysine 27 trimethylation
Core Tip Protein kinase C-interacting cousin of thioredoxin (PICOT) is a cell growth-regulating protein that interacts with embryonic ectoderm development, a core component of the polycomb repressive complex 2. PICOT is able to alter the extent of the tri-methylation of histone 3 lysine 27 at the promoter region of the polycomb repressive complex 2 target gene, CCND2, which encodes the cell cycle-regulating protein, cyclin D2. High expression levels of PICOT correlates with low expression levels of CCND2 and poor survival of a large number of human cancer patients. The results suggest that a high PICOT/CCND2 expression level ratio might serve as a predictor of patient survival in selected types of human cancer.
Publish Date 2020-05-27 13:47
Citation Pandya P, Isakov N. PICOT promotes T lymphocyte proliferation by down-regulating cyclin D2 expression. World J Immunol 2020; 10(1): 1-12
URL https://www.wjgnet.com/2219-2824/full/v10/i1/1.htm
DOI https://dx.doi.org/10.5411/wji.v10.i1.1
Full Article (PDF) WJI-10-1.pdf
Full Article (Word) WJI-10-1.docx
Manuscript File 54388-Review.docx
Answering Reviewers 54388-Answering reviewers.pdf
Audio Core Tip 54388-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 54388-Conflict-of-interest statement.pdf
Copyright License Agreement 54388-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 54388-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 54388-Language certificate.pdf
Peer-review Report 54388-Peer-review(s).pdf
Scientific Misconduct Check 54388-Bing-Zhang H-1.png
Scientific Misconduct Check 54388-Bing-Dou Y-2.png
Scientific Misconduct Check 54388-Scientific misconduct check.pdf
Scientific Editor Work List 54388-Scientific editor work list.pdf