Publication Name	World Journal of Cardiology
Manuscript ID	54539
Country	Greece

Received	2020-02-04 15:49
Peer-Review Started	2020-02-04 15:49
To Make the First Decision
Return for Revision	2020-03-24 15:03
Revised	2020-05-02 21:04
Second Decision	2020-05-25 06:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-05-27 18:53
Articles in Press	2020-05-27 18:53
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-06-03 06:06
Typeset the Manuscript	2020-07-24 03:12
Publish the Manuscript Online	2020-07-24 13:08

ISSN	1949-8462 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Comprehensive review of hemolysis in ventricular assist devices
Manuscript Source	Invited Manuscript
All Author List	Christos A Papanastasiou, Konstantinos G Kyriakoulis, Christina A Theochari, Damianos G Kokkinidis, Theodoros D Karamitsos and Leonidas Palaiodimos
Funding Agency and Grant Number
Corresponding Author	Leonidas Palaiodimos, MD, MSc, Assistant Professor, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, 111 east 210th street, Bronx, NY 10467, United States. palaiodimosmd@gmail.com
Key Words	Ventricular assist device; Hemolysis; Thrombosis; ; ;
Core Tip	Ventricular assist devices are indispensable parts of end-stage heart failure management. Severe hemolysis can be a significant complication, leading to increased mortality and worse outcomes. Incidence varies (5%-18%) depending on different hemolysis definitions and among different ventricular assist device generations. Main pathogenetic mechanisms include increased red blood cells shear stress or underlying device thrombosis. Personalized approach is crucial in the absence of certain algorithms for the management of this complication. Close clinical and laboratory monitoring in combination with imaging examinations could play a role in revealing the underlying cause. Treatment includes pharmacological (antithrombotic treatment) or surgical interventions.
Publish Date	2020-07-24 13:08
Citation	Papanastasiou CA, Kyriakoulis KG, Theochari CA, Kokkinidis DG, Karamitsos TD, Palaiodimos L. Comprehensive review of hemolysis in ventricular assist devices. World J Cardiol 2020; 12(7): 334-341
URL	https://www.wjgnet.com/1949-8462/full/v12/i7/334.htm
DOI	https://dx.doi.org/10.4330/wjc.v12.i7.334

Full Article (PDF)	WJC-12-334.pdf
Full Article (Word)	WJC-7-334.docx
Manuscript File	54539-Review-Webster J.docx
Answering Reviewers	54539-Answering reviewers.pdf
Audio Core Tip	54539-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	54539-Conflict-of-interest statement.pdf
Copyright License Agreement	54539-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	54539-Language certificate.pdf
Peer-review Report	54539-Peer-review(s).pdf
Scientific Misconduct Check	54539-Bing-Zhang L-2.png
Scientific Misconduct Check	54539-Scientific misconduct check.pdf
Scientific Editor Work List	54539-Scientific editor work list.pdf