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6/26/2020 10:39:22 AM | Browse: 26 | Download: 25
Publication Name World Journal of Stem Cells
Manuscript ID 54689
Country/Territory South Korea
Received
2020-02-21 07:24
Peer-Review Started
2020-02-21 07:25
To Make the First Decision
Return for Revision
2020-03-30 16:33
Revised
2020-04-24 13:23
Second Decision
2020-05-11 12:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-05-12 23:05
Articles in Press
2020-05-12 23:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-05-20 00:16
Typeset the Manuscript
2020-06-23 19:11
Publish the Manuscript Online
2020-06-25 10:09
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Orthopedics
Manuscript Type Retrospective Study
Article Title High tibial osteotomy with human umbilical cord blood-derived mesenchymal stem cells implantation for knee cartilage regeneration
Manuscript Source Invited Manuscript
All Author List Jun-Seob Song, Ki-Taek Hong, Chae-Gwan Kong, Na-Min Kim, Jae-Yub Jung, Han-Soo Park, Young Ju Kim, Ki Bong Chang and Seok Jung Kim
Funding Agency and Grant Number
Corresponding author Seok Jung Kim, FRCS, MD, PhD, Director, Professor, Surgeon, Department of Orthopedic Surgery, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 271, Cheonbo-ro, Uijeongbu-si 11765, Gyeonggi-do, South Korea. peter@catholic.ac.kr
Keywords Allogeneic; Human umbilical cord blood-derived mesenchymal stem cells; Cartilage regeneration; High tibial osteotomy; Osteoarthritic knees; Arthroscopy
Core Tip This is the first study to evaluate clinical outcomes and cartilage regeneration via second-look arthroscopy after implantation of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) with concomitant high tibial osteotomy (HTO) for treatment of osteoarthritic knee with varus deformity. HTO treatment of medial compartment osteoarthritis of the knee with varus deformity alone does not sufficiently repair arthritic joints. However, HTO decreases pressure in the medial compartment, providing an environment in which damaged cartilage can be regenerated via implantation of allogenic hUCB-MSCs. hUCB-MSC implantation with HTO is an effective treatment for patients with osteoarthritis of the knee with varus deformity, leading to improved clinical outcomes.
Publish Date 2020-06-25 10:09
Citation Song JS, Hong KT, Kong CG, Kim NM, Jung JY, Park HS, Kim YJ, Chang KB, Kim SJ. High tibial osteotomy with human umbilical cord blood-derived mesenchymal stem cells implantation for knee cartilage regeneration. World J Stem Cells 2020; 12(6): 514-526
Url https://www.wjgnet.com/1948-0210/full/v12/i6/514.htm
DOI https://dx.doi.org/10.4252/wjsc.v12.i6.514
Full Article (PDF) WJSC-12-514.pdf
Full Article (Word) WJSC-12-514.docx
Manuscript File 54689-Review_WangTQ.docx
Answering Reviewers 54689-Answering reviewers.pdf
Audio Core Tip 54689-Audio core tip.m4a
Biostatistics Review Certificate 54689-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 54689-Conflict-of-interest statement.pdf
Copyright License Agreement 54689-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 54689-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 54689-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 54689-Language certificate.pdf
Peer-review Report 54689-Peer-review(s).pdf
Scientific Misconduct Check 54689-Scientific misconduct check.pdf
Scientific Editor Work List 54689-Scientific editor work list.pdf