| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Analysis of long noncoding RNA-associated competing endogenous RNA network in glucagon-like peptide-1 receptor agonist-mediated protection in β cells
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Juan Cui, Tao Bai, Lin-Ping Zhi, Zhi-Hong Liu, Tao Liu, Huan Xue, Huan-Huan Yang, Xiao-Hua Yang, Min Zhang, Ya-Ru Niu, Yun-Feng Liu and Yi Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China (General Program) |
81670710 |
| National Natural Science Foundation of China (General Program) |
81770776 |
| National Natural Science Foundation of China (General Program) |
81973378 |
| Cultivate Scientific Research Excellence Programs of Higher Education Institutions in Shanxi |
2019KJ02 |
| Advanced Programs of Shanxi for the Returned Overseas Chinese Scholars |
2016-97 |
| Research Project Supported by the Shanxi Scholarship Council of China |
2017-053 |
| FSKSC and 1331KSC, Department of Education Innovation Project in Shanxi Province |
2019BY078 |
| Shanxi Youth Science and Technology Research Fund |
201901D211323 |
| Innovation and Entrepreneurship Training Program for College Students in Shanxi Province |
2019165 |
| 136 project in Shanxi Bethune Hospital |
2019XY015 |
|
| Corresponding Author |
Yi Zhang, PhD, Professor, Department of Pharmacology, Basic Medical College, Shanxi Medical University, No. 56, Xinjian South Road, Taiyuan 030001, Shanxi Province, China. yizhang313@163.com |
| Key Words |
Type 2 diabetes; β cell; Long noncoding RNA; Competing endogenous RNA; Co-expression analysis; Glucagon-like peptide-1 receptor agonist |
| Core Tip |
This study investigated the long noncoding RNAs (lncRNAs) regulatory network involved in the protective effects of geniposide, a glucagon-like peptide-1 receptor agonist (GLP-1RA), in pancreatic β cells using a microarray. We identified key lncRNAs and mRNAs, and highlighted how they interact through the competing endogenous RNA mechanism to mediate GLP-1RA protection in β cells. Our study has contributed to a deeper understanding of the molecular mechanism of β cell protection by GLP-1RA at the transcript level. |
| Publish Date |
2020-09-11 07:11 |
| Citation |
Cui LJ, Bai T, Zhi LP, Liu ZH, Liu T, Xue H, Yang HH, Yang XH, Zhang M, Niu YR, Liu YF, Zhang Y. Analysis of long noncoding RNA-associated competing endogenous RNA network in glucagon-like peptide-1 receptor agonist-mediated protection in β cells. World J Diabetes 2020; 11(9): 374-390 |
| URL |
https://www.wjgnet.com/1948-9358/full/v11/i9/374.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v11.i9.374 |
