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9/10/2020 7:50:29 AM | Browse: 33 | Download: 51
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 56061
Country/Territory Portugal
Received
2020-04-15 11:42
Peer-Review Started
2020-04-15 11:43
To Make the First Decision
Return for Revision
2020-07-05 14:50
Revised
2020-07-18 23:51
Second Decision
2020-07-29 07:21
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-08-01 21:13
Articles in Press
2020-08-01 21:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-08-04 17:32
Typeset the Manuscript
2020-09-04 01:04
Publish the Manuscript Online
2020-09-10 05:57
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Observational Study
Article Title Methylation changes at the GNAS imprinted locus in pancreatic cystic neoplasms are important for the diagnosis of malignant cysts
Manuscript Source Unsolicited Manuscript
All Author List Sandra Faias, Marlene Duarte, Luísa Pereira, Paula Chaves, Marília Cravo, Antonio Dias Pereira and Cristina Albuquerque
Funding Agency and Grant Number
Funding Agency Grant Number
Sociedade Portuguesa de Endoscopia Digestiva in 2018
Corresponding author Sandra Faias, MD, Attending Doctor, Research Fellow, Department of Gastroenterology, Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE, Rua Prof Lima Basto, Lisboa 1099-023, Portugal. sandrarfaias@hotmail.com
Key Words Intraductal papillary mucinous neoplasms; Pancreas cyst; Methylation; Biomarker; GNAS locus; Pancreatic neoplasm
Core Tip Pancreatic cystic lesions are a clinical dilemma due to risk of malignancy. Somatic mutations of GNAS are characteristic of intraductal papillary mucinous neoplasms. We found methylation changes in differential methylated regions at the GNAS locus in pancreatic cyst fluid predominantly of malignant cysts. Methylation changes in GNAS locus may improve the diagnosis of malignant cysts and shed light on the development of novel therapeutic approaches for pancreatic cancer.
Publish Date 2020-09-10 05:57
Citation Faias S, Duarte M, Pereira L, Chaves P, Cravo M, Dias Pereira A, Albuquerque C. Methylation changes at the GNAS imprinted locus in pancreatic cystic neoplasms are important for the diagnosis of malignant cysts. World J Gastrointest Oncol 2020; 12(9): 1056-1064
Url https://www.wjgnet.com/1948-5204/full/v12/i9/1056.htm
DOI https://dx.doi.org/10.4251/wjgo.v12.i9.1056
Full Article (PDF) WJGO-12-1056.pdf
Full Article (Word) WJGO-12-1056.docx
Manuscript File 56061-Review-Filipodia.docx
Answering Reviewers 56061-Answering reviewers.pdf
Audio Core Tip 56061-Audio core tip.m4a
Biostatistics Review Certificate 56061-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 56061-Conflict-of-interest statement.pdf
Copyright License Agreement 56061-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 56061-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 56061-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 56061-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 56061-Language certificate.pdf
Peer-review Report 56061-Peer-review(s).pdf
Scientific Misconduct Check 56061-Scientific misconduct check.pdf
Scientific Editor Work List 56061-Scientific editor work list.pdf