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9/10/2020 7:50:29 AM | Browse: 385 | Download: 764
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Received |
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2020-04-15 11:42 |
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Peer-Review Started |
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2020-04-15 11:43 |
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To Make the First Decision |
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Return for Revision |
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2020-07-05 14:50 |
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Revised |
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2020-07-18 23:51 |
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Second Decision |
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2020-07-29 07:21 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-08-01 21:13 |
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Articles in Press |
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2020-08-01 21:13 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-08-04 17:32 |
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Typeset the Manuscript |
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2020-09-04 01:04 |
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Publish the Manuscript Online |
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2020-09-10 05:57 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Observational Study |
| Article Title |
Methylation changes at the GNAS imprinted locus in pancreatic cystic neoplasms are important for the diagnosis of malignant cysts
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sandra Faias, Marlene Duarte, Luísa Pereira, Paula Chaves, Marília Cravo, Antonio Dias Pereira and Cristina Albuquerque |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Sociedade Portuguesa de Endoscopia Digestiva in 2018 |
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| Corresponding Author |
Sandra Faias, MD, Attending Doctor, Research Fellow, Department of Gastroenterology, Instituto Português de Oncologia de Lisboa Francisco Gentil, EPE, Rua Prof Lima Basto, Lisboa 1099-023, Portugal. sandrarfaias@hotmail.com |
| Key Words |
Intraductal papillary mucinous neoplasms; Pancreas cyst; Methylation; Biomarker; GNAS locus; Pancreatic neoplasm |
| Core Tip |
Pancreatic cystic lesions are a clinical dilemma due to risk of malignancy. Somatic mutations of GNAS are characteristic of intraductal papillary mucinous neoplasms. We found methylation changes in differential methylated regions at the GNAS locus in pancreatic cyst fluid predominantly of malignant cysts. Methylation changes in GNAS locus may improve the diagnosis of malignant cysts and shed light on the development of novel therapeutic approaches for pancreatic cancer. |
| Publish Date |
2020-09-10 05:57 |
| Citation |
Faias S, Duarte M, Pereira L, Chaves P, Cravo M, Dias Pereira A, Albuquerque C. Methylation changes at the GNAS imprinted locus in pancreatic cystic neoplasms are important for the diagnosis of malignant cysts. World J Gastrointest Oncol 2020; 12(9): 1056-1064 |
| URL |
https://www.wjgnet.com/1948-5204/full/v12/i9/1056.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v12.i9.1056 |
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