| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Validation of genetic variants associated with metabolic dysfunction-associated fatty liver disease in an ethnic-Chinese population
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Guan Huei Lee, Wah Wah Phyo, Wai Mun Loo, Raymond Kwok, Taufique Ahmed, Asim Shabbir, Jimmy So, Calvin Jianyi Koh, Juanda Leo Hartono, Mark Muthiah, Kieron Lim, Poh Seng Tan, Yin Mei Lee, Seng Gee Lim and Yock Young Dan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National University Health System |
NUHSRO/2013/226/CRG/08 |
|
| Corresponding Author |
Guan Huei Lee, MBBS, PhD, Doctor, Doctor, Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, 1E Kent Ridge Road, NUHS Tower Block, Singapore 119228, Singapore. mdcleegh@nus.edu.sg |
| Key Words |
Single nucleotide polymorphism; PNPLA3; Genotyping; Metabolic dysfunction-associated fatty liver disease; Non-alcoholic steatohepatitis; Hypertriglyceridemia |
| Core Tip |
A number of genetic variations (known as single nucleotide polymorphism, SNP) have been reported to be associated with metabolic dysfunction-associated fatty liver disease (MAFLD), mostly by studies from Europe and America. This study examines 10 of the most important SNPs in a Chinese population in Singapore, and found that one such variation, the PNPLA3 GG variation, is strongly linked to MAFLD, while the rest are not significantly associated. PNPLA3, together with high triglyceride and elevated body mass index, are found to be independent, strong predictors of MAFLD. |
| Publish Date |
2020-12-18 05:58 |
| Citation |
Lee GH, Phyo WW, Loo WM, Kwok R, Ahmed T, Shabbir A, So J, Koh CJ, Hartono JL, Muthiah M, Lim K, Tan PS, Lee YM, Lim SG, Dan YY. Validation of genetic variants associated with metabolic dysfunction-associated fatty liver disease in an ethnic-Chinese population. World J Hepatol 2020; 12(12): 1228-1238 |
| URL |
https://www.wjgnet.com/1948-5182/full/v12/i12/1228.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v12.i12.1228 |
