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11/13/2020 9:30:44 AM | Browse: 335 | Download: 701
Publication Name World Journal of Gastroenterology
Manuscript ID 57827
Country/Territory South Korea
Received
2020-06-26 08:03
Peer-Review Started
2020-06-26 08:03
To Make the First Decision
Return for Revision
2020-08-22 21:48
Revised
2020-08-27 05:34
Second Decision
2020-09-22 10:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-09-22 20:35
Articles in Press
2020-09-22 20:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-11-12 02:15
Publish the Manuscript Online
2020-11-13 06:52
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Reactive oxygen species-induced activation of Yes-associated protein-1 through the c-Myc pathway is a therapeutic target in hepatocellular carcinoma
Manuscript Source Invited Manuscript
All Author List Yuri Cho, Min Ji Park, Koeun Kim, Sun Woong Kim, Wonjin Kim, Sooyeon Oh and Joo Ho Lee
Funding Agency and Grant Number
Funding Agency Grant Number
National Research Foundation of Korea grant funded by the Korea government 2018R1C1B6001102
Research Supporting Program of the Korean Association for the Study of the Liver and The Korean Liver Foundation year: 2017
Corresponding Author Yuri Cho, MD, PhD, Assistant Professor, Department of Internal Medicine, CHA Gangnam Medical Center, CHA University School of Medicine, No. 569 Nonhyon-ro, Gangnam-gu, Seoul 06135, South Korea. yuricho@cha.ac.kr
Key Words Hepatocellular carcinoma; Yes-associated protein-1; C-Myc; Reactive oxygen species; Unfolded protein response; Activating transcription factor-6
Core Tip We found a novel connection between yes-associated protein-1 (YAP-1) and the unfolded protein response (UPR) through the c-Myc pathway during oxidative stress in hepatocellular carcinoma (HCC). As the Hippo pathway and c-Myc pathway share many important functions, including the regulation of growth, death and survival in cells and the regulation of stress resistance and life spans in organisms, we speculate that the interaction between YAP-1 and c-Myc is a point of convergence that allows HCC proliferation. The reactive oxygen species-induced activation of YAP-1 via the c-Myc pathway, which leads to the activation of the UPR pathway, might be a therapeutic target in HCC.
Publish Date 2020-11-13 06:52
Citation Cho Y, Park MJ, Kim K, Kim SW, Kim W, Oh S, Lee JH. Reactive oxygen species-induced activation of Yes-associated protein-1 through the c-Myc pathway is a therapeutic target in hepatocellular carcinoma. World J Gastroenterol 2020; 26(42): 6599-6613
URL https://www.wjgnet.com/1007-9327/full/v26/i42/6599.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i42.6599
Full Article (PDF) WJG-26-6599.pdf
Full Article (Word) WJG-26-6599.docx
Manuscript File 57827-Review.docx
Answering Reviewers 57827-Answering reviewers.pdf
Audio Core Tip 57827-Audio core tip.m4a
Biostatistics Review Certificate 57827-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 57827-Conflict-of-interest statement.pdf
Copyright License Agreement 57827-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 57827-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 57827-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 57827-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 57827-Language certificate.pdf
Peer-review Report 57827-Peer-review(s).pdf
Scientific Misconduct Check 57827-Bing-Yan JP-1.png
Scientific Misconduct Check 57827-Bing-Fan JR-2.png
Scientific Misconduct Check 57827-Scientific misconduct check.pdf
Scientific Editor Work List 57827-Scientific editor work list.pdf