Publication Name	World Journal of Hepatology
Manuscript ID	58114
Country	United States

Received	2020-07-08 02:38
Peer-Review Started	2020-07-08 02:39
To Make the First Decision
Return for Revision	2020-07-30 17:50
Revised	2020-07-31 20:08
Second Decision	2020-08-11 07:20
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-08-15 21:56
Articles in Press	2020-08-15 21:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-08-24 00:28
Publish the Manuscript Online	2020-09-21 16:02

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Clinical implications, diagnosis, and management of diabetes in patients with chronic liver diseases
Manuscript Source	Unsolicited Manuscript
All Author List	Waihong Chung, Kittichai Promrat and Jack Wands
Funding Agency and Grant Number
Corresponding Author	Waihong Chung, MD, PhD, Doctor, Research Fellow, Division of Gastroenterology, Department of Medicine, Rhode Island Hospital, 245 Chapman Street, Suite 300, Providence, RI 02905, United States. waihongchung@gmail.com
Key Words	End stage liver disease; Diabetes mellitus; Liver cirrhosis; Insulin resistance; Non-alcoholic fatty liver disease; Liver diseases
Core Tip	Diabetes is an independent risk factor for the development and progression of chronic liver disease (CLD) of various etiologies. Concurrent diabetes and CLD predict worse clinical outcomes, including hepatic decompensation, hepatocellular carcinoma (HCC), and complications following liver transplantation. Traditional glycemic markers, including fasting glucose, oral glucose tolerance test, and hemoglobin A1c, are not accurate in patients with severe CLD. Metformin and α-glucosidase inhibitors are associated with significant benefits beyond glycemic control, including reductions in HCC risk and incidence of hepatic encephalopathy. Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors may exert a hepatic protective effect irrespective of the degree of glycemic control.
Publish Date	2020-09-21 16:02
Citation	Chung W, Promrat K, Wands J. Clinical implications, diagnosis, and management of diabetes in patients with chronic liver diseases. World J Hepatol 2020; 12(9): 533-557
URL	https://www.wjgnet.com/1948-5182/full/v12/i9/533.htm
DOI	https://dx.doi.org/10.4254/wjh.v12.i9.533

Full Article (PDF)	WJH-12-533.pdf
Full Article (Word)	WJH-12-533.docx
Manuscript File	58114-Review.docx
Answering Reviewers	58114-Answering reviewers.pdf
Audio Core Tip	58114-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	58114-Conflict-of-interest statement.pdf
Copyright License Agreement	58114-Copyright license agreement.pdf
Supplementary Material	58114-Supplementary material.pdf
Peer-review Report	58114-Peer-review(s).pdf
Scientific Misconduct Check	58114-Bing-Gong ZM-2.png
Scientific Misconduct Check	58114-Scientific misconduct check.pdf
Scientific Editor Work List	58114-Scientific editor work list.pdf