| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Basic Study |
| Article Title |
Pathological significance of abnormal recepteur d’origine nantais and programmed death ligand 1 expression in colorectal cancer
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Yi-Zhi Liu, Da-Ting Han, Dan-Rong Shi, Bo Hong, Yun Qian, Zhi-Gang Wu, Shu-Hao Yao, Tao-Ming Tang, Ming-Hai Wang, Xiang-Ming Xu and Hang-Ping Yao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Zhejiang Provincial Natural Science Foundation of China grant |
LY18H160014 (to XMX) |
| National Natural Science Foundation of China grant |
81872883 (to HPY) |
| Zhejiang Major Medical Health & Sciences Technology Foundation Projects |
WKJ-ZJ-13 (to HPY) |
|
| Corresponding Author |
Hang-Ping Yao, PhD, Professor, Department of Cancer Biology Research, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. yaohangping@zju.edu.cn |
| Key Words |
Colorectal cancer; Programmed death ligand 1; Prognosis; Recepteur d’origine nantais; Tumor infiltrating mononuclear cells; Tumor microenvironment |
| Core Tip |
Recepteur d’origine nantais (RON) expression plays an important role in regulating tumor immunity, and the efficacy of programmed death ligand 1 (PD-L1) immunotherapy in colorectal cancer (CRC) is still not satisfactory. This inspired us to study the clinical significance and correlation of RON and PD-L1 in CRC. The major discoveries and findings in this study are: (1) The abnormal expression of RON and PD-L1 are not only correlated, but are significant biomarkers for poor prognosis of CRC. This finding was identified in 389 primary CRC clinical samples via multiplex immunofluorescence staining and immunohistochemistry staining. And (2) We show in in vitro experiments that activation of RON phosphorylation up-regulates the expression of PD-L1 in CRC cells. |
| Publish Date |
2020-11-12 03:59 |
| Citation |
Liu YZ, Han DT, Shi DR, Hong B, Qian Y, Wu ZG, Yao SH, Tang TM, Wang MH, Xu XM, Yao HP. Pathological significance of abnormal recepteur d’origine nantais and programmed death ligand 1 expression in colorectal cancer. World J Gastrointest Oncol 2020; 12(11): 1216-1236 |
| URL |
https://www.wjgnet.com/1948-5204/full/v12/i11/1216.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v12.i11.1216 |
