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12/27/2020 5:56:55 AM | Browse: 272 | Download: 616
Publication Name World Journal of Stem Cells
Manuscript ID 59216
Country/Territory Spain
Received
2020-09-03 20:37
Peer-Review Started
2020-09-03 20:38
To Make the First Decision
Return for Revision
2020-09-15 22:16
Revised
2020-09-30 01:00
Second Decision
2020-10-20 12:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-10-20 21:22
Articles in Press
2020-10-20 21:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-12-24 02:30
Publish the Manuscript Online
2020-12-27 05:30
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research & Experimental
Manuscript Type Basic Study
Article Title Effects of normobaric cyclic hypoxia exposure on mesenchymal stem-cell differentiation–pilot study on bone parameters in elderly
Manuscript Source Invited Manuscript
All Author List Marta Camacho-Cardenosa, José Manuel Quesada-Gómez, Alba Camacho-Cardenosa, Alejo Leal, Gabriel Dorado, Bárbara Torrecillas-Baena and Antonio Casado-Diaz
Funding Agency and Grant Number
Funding Agency Grant Number
Government of Extremadura GAEDAF Research Group GR18003
Ministerio de Educación, Cultura y Deporte FPU15/00452
Instituto de Salud Carlos III PI15/01857
Instituto de Salud Carlos III PI18/01659
Corresponding Author Marta Camacho-Cardenosa, PhD, Postdoc, Facultad Ciencias Del Deporte, Universidad De Extremadura, Av. Universidad, s/n , Cáceres 10003, Spain. mcamachocardenosa@unex.es
Key Words Normobaric cyclic hypoxia; Mesenchymal stem cells; cellular differentiation; Osteoblast; Adipocytes; Bone health
Core Tip Cyclic hypoxia (CH) can improve bone health in aging. Mesenchymal stem cells were induced to differentiate into osteoblasts or adipocytes, in hypoxia (3% O2) for 1, 2 or 4 h, 4 d a week. Older people were treated with 36 CH sessions of 16 min (simulating an altitude of 2500 m), for 18 wk. Exposure to longer periods of hypoxia inhibited mesenchymal stem cells differentiation, but increased osteoprotegerin/receptor activator for nuclear factor kappa B ligand expression in both cell types. CH increased total bone mineral density, but not fat content, in elderly. CH may improve bone health in elderly, due to its inhibitory effect on bone resorption, by increasing the osteoprotegerin/receptor activator for nuclear factor kappa B ligand ratio.
Publish Date 2020-12-27 05:30
Citation Camacho-Cardenosa M, Quesada-Gómez JM, Camacho-Cardenosa A, Leal A, Dorado G, Torrecillas-Baena B, Casado-Diaz A. Effects of normobaric cyclic hypoxia exposure on mesenchymal stem-cell differentiation–pilot study on bone parameters in elderly. World J Stem Cells 2020; 12(12): 1667-1690
URL https://www.wjgnet.com/1948-0210/full/v12/i12/1667.htm
DOI https://dx.doi.org/10.4252/wjsc.v12.i12.1667
Full Article (PDF) WJSC-12-1667.pdf
Full Article (Word) WJSC-12-1667.docx
Manuscript File 59216_Auto_Edited.docx
Answering Reviewers 59216-Answering reviewers.pdf
Audio Core Tip 59216-Audio core tip.opus
Biostatistics Review Certificate 59216-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 59216-Conflict-of-interest statement.pdf
Copyright License Agreement 59216-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 59216-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 59216-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 59216-Language certificate.pdf
Peer-review Report 59216-Peer-review(s).pdf
Scientific Misconduct Check 59216-Scientific misconduct check.pdf
Scientific Editor Work List 59216-Scientific editor work list.pdf