| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Histopathology and predominantly progressive, indeterminate and predominately regressive score in hepatitis C virus patients after direct-acting antivirals therapy
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Rui Huang, Hui-Ying Rao, Ming Yang, Ying-Hui Gao, Jian Wang, Qian Jin, Dan-Li Ma and Lai Wei |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81870406 |
| Beijing Natural Science Foundation |
7182174 |
| China National Science and Technology Major Project for Infectious Diseases Control during the 13th Five-Year Plan Period |
2017ZX10202202 |
|
| Corresponding Author |
Hui-Ying Rao, MD, Chief Doctor, Professor, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing International Cooperation Base for Science and Technology on NAFLD Diagnosis, Peking University People’s Hospital, No. 11 Xizhimen South Street, Xicheng District, Beijing 100044, China. raohuiying@pkuph.edu.cn |
| Key Words |
hepatitis C virus; direct-acting antiviral agents; necroinflammation; fibrosis; P-I-R score; Histopathology |
| Core Tip |
In this retrospective analysis of paired liver biopsy specimens from hepatitis C virus (HCV) patients who achieved sustained virologic response after direct-acting antivirals (DAAs) therapy, clinical and histologic features including Ishak system and predominantly progressive, indeterminate and predominately regressive (P-I-R) scores were analyzed. Significant improvement of necroinflammation and partial remission of fibrosis in HCV patients occurred shortly after DAAs therapy. Usage of P-I-R score for prediction of fibrosis in HCV patients was potential. |
| Publish Date |
2021-01-29 07:57 |
| Citation |
Huang R, Rao HY, Yang M, Gao YH, Wang J, Jin Q, Ma DL, Wei L. Histopathology and predominantly progressive, indeterminate and predominately regressive score in hepatitis C virus patients after direct-acting antivirals therapy. World J Gastroenterol 2021; 27(5): 404-415 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i5/404.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i5.404 |
