Publication Name	World Journal of Gastroenterology
Manuscript ID	60125
Country	China

Received	2020-10-16 08:28
Peer-Review Started	2020-10-16 08:29
To Make the First Decision
Return for Revision	2020-11-03 14:00
Revised	2020-11-15 12:22
Second Decision	2020-11-30 09:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-12-06 01:47
Articles in Press	2020-12-06 01:47
Publication Fee Transferred
Edit the Manuscript by Language Editor	2020-12-11 22:25
Typeset the Manuscript	2020-12-21 01:39
Publish the Manuscript Online	2020-12-25 10:20

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Microbiology
Manuscript Type	Observational Study
Article Title	Oral microbiome and pancreatic cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Ai-Lin Wei, Mao Li, Guo-Qing Li, Xuan Wang, Wei-Ming Hu, Zhen-Lu Li, Jue Yuan, Hong-Ying Liu, Li-Li Zhou, Ka Li, Ang Li and Mei Rosemary Fu
Funding Agency and Grant Number	Funding Agency Grant Number Expert Funding of National Natural Science Foundation of China No. 81773174 1·3·5 project for disciplines of excellence- Clinical Research Incubation and Innovation Project , West China Hospital, Sichuan University No. ZYJC18044 Clinical Research Incubation and Innovation Project of West China Hospital No. 2019HXFH009 Science and technology project of Sichuan Province No. 2020YFS0264
Corresponding Author	Ang Li, MD, Professor, Department of Pancreatic Surgery, West China Hospital, Sichuan University, NO. 37 Guoxue Alley, Chengdu 610000, Sichuan Province, China. angli@scu.edu.cn
Key Words	Oral microbiota; Dysbiosis; Pancreatic cancer; Cancer detection; 16s rRNA; High-throughput sequencing
Core Tip	Pancreatic adenocarcinoma (PDAC) patients benefit from early detection. This study analyzed the composition and diversity of saliva microbiota in PDAC patients through 16S rRNA sequencing. Normalized z-score of bacteria abundance associated clinical data were analyzed for PDAC risk prediction. Microbiome abundance differences were found between PDAC patients with symptoms and patients without symptoms. Combined symptom and microbiome evaluation may help in early detection and risk prediction of pancreatic cancer.
Publish Date	2020-12-25 10:20
Citation	Wei AL, Li M, Li GQ, Wang X, Hu WM, Li ZL, Yuan J, Liu HY, Zhou LL, Li K, Li A, Fu MR. Oral microbiome and Pancreatic Cancer. World J Gastroenterol 2020; 26(48): 7679-7692
URL	https://www.wjgnet.com/1007-9327/full/v26/i48/7679.htm
DOI	https://dx.doi.org/10.3748/wjg.v26.i48.7679

Full Article (PDF)	WJG-26-7679.pdf
Full Article (Word)	WJG-26-7679.docx
Manuscript File	60125-Review-FilipodiaCL.docx
Answering Reviewers	60125-Answering reviewers.pdf
Audio Core Tip	60125-Audio core tip.m4a
Biostatistics Review Certificate	60125-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	60125-Conflict-of-interest statement.pdf
Copyright License Agreement	60125-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	60125-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	60125-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	60125-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	60125-Language certificate.pdf
Peer-review Report	60125-Peer-review(s).pdf
Scientific Misconduct Check	60125-Bing-Yan JP-1.png
Scientific Misconduct Check	60125-Bing-Fan JR-2.png
Scientific Misconduct Check	60125-Scientific misconduct check.pdf
Scientific Editor Work List	60125-Scientific editor work list.pdf
CrossCheck Report	60125-CrossCheck Report.pdf
CrossCheck Report	60125-CrossCheck.png