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2/23/2021 2:49:34 AM | Browse: 275 | Download: 597
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Received |
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2020-12-14 15:39 |
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Peer-Review Started |
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2020-12-14 15:41 |
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To Make the First Decision |
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Return for Revision |
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2020-12-24 19:05 |
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Revised |
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2021-01-04 19:15 |
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Second Decision |
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2021-01-12 06:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2021-01-21 22:16 |
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Articles in Press |
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2021-01-21 22:16 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2021-02-01 05:38 |
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Publish the Manuscript Online |
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2021-02-22 12:47 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Racial disparities in immune-related adverse events of immune checkpoint inhibitors and association with survival based on clinical and biochemical responses
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Monica Peravali, Cristiane Gomes-Lima, Eshetu Tefera, Mairead Baker, Mamta Sherchan, Saira Farid, Kenneth Burman, Florina Constantinescu and Irina Veytsman |
| Funding Agency and Grant Number |
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| Corresponding Author |
Monica Peravali, MD, Academic Fellow, Department of Hematology/Oncology, MedStar Washington Hospital Center, 110 Irving Street, Washington, DC 20010, United States. monica.peravali@medstar.net |
| Key Words |
Immunotherapy; Adverse events; Endocrine; Survival; Race; Minority |
| Core Tip |
Immune checkpoint inhibitors have revolutionized the treatment of many types of cancer, yet they cause various immune-related adverse events (irAEs), notably thyroid dysfunction. Development of irAEs has been reported as a surrogate marker of improved survival. However, minority racial group representation is a limitation in immunotherapy trials. In this retrospective study, we evaluate the association of development of irAEs to survival outcomes in patients treated with immune checkpoint inhibitors for advanced stage solid malignancies. The racial diversity of the population of patients is a unique feature of this study. Our data concluded a positive correlation of irAEs development with increased probability of survival and demonstrates a positive correlation with Caucasian race and overall survival. |
| Publish Date |
2021-02-22 12:47 |
| Citation |
Peravali M, Gomes-Lima C, Tefera E, Baker M, Sherchan M, Farid S, Burman K, Constantinescu F, Veytsman I. Racial disparities in immune-related adverse events of immune checkpoint inhibitors and association with survival based on clinical and biochemical responses. World J Clin Oncol 2021; 12(2): 103-114 |
| URL |
https://www.wjgnet.com/2218-4333/full/v12/i2/103.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v12.i2.103 |
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