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4/21/2021 8:05:01 AM | Browse: 283 | Download: 521
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Received |
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2021-01-10 13:30 |
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Peer-Review Started |
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2021-01-10 13:31 |
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To Make the First Decision |
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Return for Revision |
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2021-02-11 01:28 |
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Revised |
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2021-02-15 01:57 |
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Second Decision |
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2021-03-22 06:38 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2021-03-22 17:24 |
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Articles in Press |
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2021-03-22 17:24 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-03-27 16:28 |
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Typeset the Manuscript |
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2021-04-19 09:10 |
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Publish the Manuscript Online |
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2021-04-21 05:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
COVID-19 severity in obesity: Metabolic dysfunction-associated fatty liver disease in the spotlight
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Isabela Macedo Lopes Vasques-Monteiro and Vanessa Souza-Mello |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Conselho Nacional de Desenvolvimento Científico e Tecnológico |
305867/2017-2 |
| Fundação de Amparo à Pesquisa do Estado Rio de Janeiro, FAPERJ |
E-26/202.657/2018 |
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| Corresponding Author |
Vanessa Souza-Mello, PhD, Associate Professor, Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, Institute of Biology, Anatomy Department, Rio de Janeiro State University, Blvd. 28 de setembro 87, Rio de Janeiro 20551030, Brazil. souzamello.uerj@gmail.com |
| Key Words |
Metabolic dysfunction-associated fatty liver disease; Obesity; COVID-19; Severity; Cytokine storm syndrome |
| Core Tip |
It is notorious that obesity represents a risk for coronavirus disease 2019 (COVID-19) severity. However, COVID-19 often causes liver alterations or provokes the progression of pre-existing liver diseases. This review outlined the role of metabolic dysfunction-associated fatty liver disease in COVID-19 severity. The evidence available thus far supports the notion that metabolic dysfunction-associated fatty liver disease represents a more intense risk than obesity to hospitalization, extended viral shedding, and death. A pro-inflammatory state with inflammasome activation, implying increased susceptibility to cytokine storm syndrome, underlies these findings and emerges as potential targets to therapeutic strategies, besides massive vaccination of subjects with liver diseases. |
| Publish Date |
2021-04-21 05:56 |
| Citation |
Vasques-Monteiro IML, Souza-Mello V. COVID-19 severity in obesity: Metabolic dysfunction-associated fatty liver disease in the spotlight. World J Gastroenterol 2021; 27(16): 1738-1750 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i16/1738.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i16.1738 |
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