Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	62648
Country	Japan

Received	2021-01-14 05:55
Peer-Review Started	2021-01-14 05:57
To Make the First Decision
Return for Revision	2021-02-14 06:36
Revised	2021-03-04 10:11
Second Decision	2021-04-20 13:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-04-22 04:42
Articles in Press	2021-04-22 04:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-04-28 01:24
Publish the Manuscript Online	2021-05-07 09:15

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Minireviews
Article Title	Molecular-targeted therapy toward precision medicine for gastrointestinal cancer: Current progress and challenges
Manuscript Source	Invited Manuscript
All Author List	Tasuku Matsuoka and Masakazu Yashiro
Funding Agency and Grant Number	Funding Agency Grant Number KAKENHI (Grant-in-Aid for Scientific Research) 18H02883
Corresponding Author	Masakazu Yashiro, MD, PhD, Associate Professor, Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan. m9312510@med.osaka-cu.ac.jp
Key Words	Gastrointestinal cancer; Esophageal cancer; Gastric cancer; Colorectal cancer; Targeted therapy; Precision medicine
Core Tip	Outcomes in metastatic gastrointestinal (GI) cancer are improving with the better understanding and use of targeted therapies. Herein, a review of the literature and recent conference presentations was conducted regarding the topic of targeted therapies for precision medicine in GI cancer. This article clarifies the current evidence for targeted therapies in GI cancer by evaluating the latest data regarding anti- epidermal growth factor receptor, human epidermal growth factor receptor 2, vascular endothelial growth factor, phosphatidylinositol-3-hydroxykinase/protein kinase B, tumor growth factor-β, mesenchymal-epithelial transition, wireless network technology, poly (ADP-ribose) polymerase, and immunotherapies.
Publish Date	2021-05-07 09:15
Citation	Matsuoka T, Yashiro M. Molecular-targeted therapy toward precision medicine for gastrointestinal caner: Current progress and challenges. World J Gastrointest Oncol 2021; 13(5): 366-390
URL	https://www.wjgnet.com/1948-5204/full/v13/i5/366.htm
DOI	https://dx.doi.org/10.4251/wjgo.v13.i5.366

Full Article (PDF)	WJGO-13-366.pdf
Full Article (Word)	WJGO-13-366.docx
Manuscript File	62648_Auto_Edited_LM.docx
Answering Reviewers	62648-Answering reviewers.pdf
Audio Core Tip	62648-Audio core tip.MP3
Conflict-of-Interest Disclosure Form	62648-Conflict-of-interest statement.pdf
Copyright License Agreement	62648-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	62648-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	62648-Language certificate.pdf
Peer-review Report	62648-Peer-review(s).pdf
Scientific Misconduct Check	62648-Bing-Wang JL-1.jpg
Scientific Misconduct Check	62648-Scientific misconduct check.pdf
Scientific Editor Work List	62648-Scientific editor work list.pdf