Publication Name	World Journal of Gastroenterology
Manuscript ID	62676
Country	United States

Received	2021-01-14 21:26
Peer-Review Started	2021-01-14 21:27
To Make the First Decision
Return for Revision	2021-03-29 05:42
Revised	2021-04-30 20:36
Second Decision	2021-09-06 03:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-09-06 11:09
Articles in Press	2021-09-06 11:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-10-09 03:14
Publish the Manuscript Online	2021-10-12 06:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Transcription factors specificity protein and nuclear receptor 4A1 in pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Stephen Safe, Rupesh Shrestha, Kumaravel Mohankumar, Marcell Howard, Erik Hedrick and Maen Abdelrahim
Funding Agency and Grant Number	Funding Agency Grant Number Houston Methodist Cancer Center Innovation Award
Corresponding Author	Stephen Safe, PhD, Full Professor, Department of Veterinary Physiology and Pharmacology, Texas A&M University, 4466 TAMU, College Station, TX 77845, United States. ssafe@cvm.tamu.edu
Key Words	Specificity protein; Nuclear receptor 4A1; Pancreatic cancer; Transcription factors; Ligand inhibitors; Nuclear receptor 4A antagonists
Core Tip	Specificity protein (Sp), transcription factors (TFs), Sp1, Sp3 and Sp4, and nuclear receptor 4A1 (NR4A1, Nur77) are highly expressed in pancreatic cancer cells and tumors. Results of gene silencing studies show that Sp TFs and NR4A1 are pro-oncogenic and regulate pathways/genes associated with cell proliferation, survival and migration/invasion. Bis-indole derived ligands (CDIMs) that bind NR4A1 act as NR4A1 antagonists and we discuss an important mechanism of gene regulation by NR4A1/Sp complexes which can be inhibited by NR4A1 antagonists.
Publish Date	2021-10-12 06:53
Citation	Safe S, Shrestha R, Mohankumar K, Howard M, Hedrick E, Abdelrahim M. Transcription factors specificity protein and nuclear receptor 4A1 in pancreatic cancer. World J Gastroenterol 2021; 27(38): 6387-6398
URL	https://www.wjgnet.com/1007-9327/full/v27/i38/6387.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i38.6387

Full Article (PDF)	WJG-27-6387.pdf
Full Article (Word)	WJG-27-6387.docx
Manuscript File	62676_Auto_Edited-MLS.docx
Answering Reviewers	62676-Answering reviewers.pdf
Audio Core Tip	62676-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	62676-Conflict-of-interest statement.pdf
Copyright License Agreement	62676-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	62676-Grant application form(s).pdf
Peer-review Report	62676-Peer-review(s).pdf
Scientific Misconduct Check	62676-Bing-Wang JL-1.jpg
Scientific Editor Work List	62676-Scientific editor work list.pdf