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10/12/2021 7:00:09 AM | Browse: 34 | Download: 69
Publication Name World Journal of Gastroenterology
Manuscript ID 62676
Country/Territory United States
2021-01-14 21:26
Peer-Review Started
2021-01-14 21:27
To Make the First Decision
Return for Revision
2021-03-29 05:42
2021-04-30 20:36
Second Decision
2021-09-06 03:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-09-06 11:09
Articles in Press
2021-09-06 11:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-10-09 03:14
Publish the Manuscript Online
2021-10-12 06:53
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Minireviews
Article Title Transcription factors specificity protein and nuclear receptor 4A1 in pancreatic cancer
Manuscript Source Invited Manuscript
All Author List Stephen Safe, Rupesh Shrestha, Kumaravel Mohankumar, Marcell Howard, Erik Hedrick and Maen Abdelrahim
Funding Agency and Grant Number
Funding Agency Grant Number
Houston Methodist Cancer Center Innovation Award
Corresponding Author Stephen Safe, PhD, Full Professor, Department of Veterinary Physiology and Pharmacology, Texas A&M University, 4466 TAMU, College Station, TX 77845, United States. ssafe@cvm.tamu.edu
Key Words Specificity protein; Nuclear receptor 4A1; Pancreatic cancer; Transcription factors; Ligand inhibitors; Nuclear receptor 4A antagonists
Core Tip Specificity protein (Sp), transcription factors (TFs), Sp1, Sp3 and Sp4, and nuclear receptor 4A1 (NR4A1, Nur77) are highly expressed in pancreatic cancer cells and tumors. Results of gene silencing studies show that Sp TFs and NR4A1 are pro-oncogenic and regulate pathways/genes associated with cell proliferation, survival and migration/invasion. Bis-indole derived ligands (CDIMs) that bind NR4A1 act as NR4A1 antagonists and we discuss an important mechanism of gene regulation by NR4A1/Sp complexes which can be inhibited by NR4A1 antagonists.
Publish Date 2021-10-12 06:53
Citation Safe S, Shrestha R, Mohankumar K, Howard M, Hedrick E, Abdelrahim M. Transcription factors specificity protein and nuclear receptor 4A1 in pancreatic cancer. World J Gastroenterol 2021; 27(38): 6387-6398
URL https://www.wjgnet.com/1007-9327/full/v27/i38/6387.htm
DOI https://dx.doi.org/10.3748/wjg.v27.i38.6387
Full Article (PDF) WJG-27-6387.pdf
Full Article (Word) WJG-27-6387.docx
Manuscript File 62676_Auto_Edited-MLS.docx
Answering Reviewers 62676-Answering reviewers.pdf
Audio Core Tip 62676-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 62676-Conflict-of-interest statement.pdf
Copyright License Agreement 62676-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 62676-Grant application form(s).pdf
Peer-review Report 62676-Peer-review(s).pdf
Scientific Misconduct Check 62676-Bing-Wang JL-1.jpg
Scientific Editor Work List 62676-Scientific editor work list.pdf