Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	62949
Country	United States

Received	2021-01-21 15:41
Peer-Review Started	2021-01-21 15:47
To Make the First Decision
Return for Revision	2021-02-10 02:05
Revised	2021-02-25 17:51
Second Decision	2021-03-31 09:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-03-31 17:30
Articles in Press	2021-03-31 17:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-05-13 07:01
Publish the Manuscript Online	2021-05-14 10:27

ISSN	2150-5330 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Platelet count as a screening tool for compensated cirrhosis in chronic viral hepatitis
Manuscript Source	Invited Manuscript
All Author List	Pallavi Surana, Julian Hercun, Varun Takyar, David E Kleiner, Theo Heller and Christopher Koh
Funding Agency and Grant Number
Corresponding Author	Christopher Koh, FAASLD, MD, MHSc, Associate Professor, Director, Doctor, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, 10 Center Drive, Room 5-2740, Bethesda, MD 20892, United States. christopher.koh@nih.gov
Key Words	Chronic hepatitis B; Chronic hepatitis C; Chronic hepatitis D; Platelets; Cirrhosis; Non-invasive assessment
Core Tip	Platelet count is a well-recognized surrogate marker for progression of liver disease, however a specific cut-off for cirrhosis has not been established. In this study, platelet counts can accurately stratify chronic viral hepatitis patients with cirrhosis; and a platelet count > 143 × 109/L appears to have the most clinical utility in ruling out cirrhosis across all chronic viral hepatitis. This widely available laboratory value may be useful in decision making for the management of patients with chronic viral hepatitis and represents a finding which may be of particular value in a primary care setting.
Publish Date	2021-05-14 10:27
Citation	Surana P, Hercun J, Takyar V, Kleiner DE, Heller T, Koh C. Platelet count as a screening tool for compensated cirrhosis in chronic viral hepatitis. World J Gastrointest Pathophysiol 2021; 12(3): 40-50
URL	https://www.wjgnet.com/2150-5330/full/v12/i3/40.htm
DOI	https://dx.doi.org/10.4291/wjgp.v12.i3.40

Full Article (PDF)	WJGP-12-40.pdf
Full Article (Word)	WJGP-12-40.docx
Manuscript File	62949_Auto_Edited_LM.docx
Answering Reviewers	62949-Answering reviewers.pdf
Audio Core Tip	62949-Audio core tip.mp3
Biostatistics Review Certificate	62949-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	62949-Conflict-of-interest statement.pdf
Copyright License Agreement	62949-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s)	62949-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	62949-Institutional review board statement.pdf
Peer-review Report	62949-Peer-review(s).pdf
Scientific Misconduct Check	62949-Scientific misconduct check.pdf
Scientific Editor Work List	62949-Scientific editor work list.pdf