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7/19/2021 2:13:13 PM | Browse: 296 | Download: 535
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Received |
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2021-01-31 11:49 |
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Peer-Review Started |
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2021-01-31 11:59 |
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To Make the First Decision |
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Return for Revision |
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2021-05-13 01:03 |
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Revised |
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2021-05-15 09:02 |
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Second Decision |
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2021-06-22 08:08 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2021-06-22 10:00 |
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Articles in Press |
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2021-06-22 10:00 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-06-25 20:46 |
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Typeset the Manuscript |
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2021-07-15 08:18 |
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Publish the Manuscript Online |
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2021-07-19 14:10 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Microbiology |
| Manuscript Type |
Minireviews |
| Article Title |
Dysregulated liver function in SARS-CoV-2 infection: Current understanding and perspectives
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yi-Ke Huang, Yu-Jia Li, Bin Li, Pan Wang and Qing-Hua Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Sino-German Center for Research Promotion, National Natural Science Foundation of China |
C-0029 |
| Health Commission of Chengdu |
2020179 |
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| Corresponding Author |
Qing-Hua Wang, MD, Chief Doctor, Department of Emergency, the Traditional Chinese Medicine Hospital of Wenjiang District, No. 156 Dongda Street, Chengdu 611130, Sichuan Province, China. qinghuawang2015@126.com |
| Key Words |
SARS-CoV-2; COVID-19; Dysregulated liver function; Cytokine storm |
| Core Tip |
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is one of the most influential emerging infectious diseases worldwide. Accumulating evidence suggests that liver injury is pretty common in COVID-19 patients and many severe cases tend to be associated with dysregulated liver functions. Here in this review, we summarize the currently available data of liver enzyme abnormalities in confirmed patients with COVID-19 and analyze multiple risk factors for liver injury. However, the mechanism of liver impairment seems to be multifactorial. The evidence of direct liver injury triggered by SARS-CoV-2 infection or indirect liver injury induced by overwhelmed cytokine storm will also be discussed. |
| Publish Date |
2021-07-19 14:10 |
| Citation |
Huang YK, Li YJ, Li B, Wang P, Wang QH. Dysregulated liver function in SARS-CoV-2 infection: Current understanding and perspectives. World J Gastroenterol 2021; 27(27): 4358-4370 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i27/4358.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i27.4358 |
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