Publication Name	World Journal of Stem Cells
Manuscript ID	63741
Country	Romania

Received	2021-02-01 16:59
Peer-Review Started	2021-02-01 17:10
To Make the First Decision
Return for Revision	2021-02-28 05:24
Revised	2021-03-11 18:22
Second Decision	2021-03-29 10:16
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-03-30 04:13
Articles in Press	2021-03-30 04:13
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-04-05 00:51
Typeset the Manuscript	2021-04-20 06:32
Publish the Manuscript Online	2021-04-22 10:31

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Review
Article Title	Patient-specific induced pluripotent stem cells as “disease-in-a-dish” models for inherited cardiomyopathies and channelopathies – 15 years of research
Manuscript Source	Invited Manuscript
All Author List	Miruna Mihaela Micheu and Ana-Maria Rosca
Funding Agency and Grant Number
Corresponding Author	Miruna Mihaela Micheu, MD, PhD, Doctor, Doctor, Department of Cardiology, Clinical Emergency Hospital of Bucharest, Floreasca Street 8, Bucharest 014452, Romania. mirunamicheu@yahoo.com
Key Words	Induced pluripotent stem cells; Cardiomyopathy; Channelopathy; Genes; Mutation; Deoxyribonucleic acid variants
Core Tip	Induced pluripotent stem cell (iPSC) technology holds a great potential for medical research. Patient-specific iPSC-derived cardiomyocytes offer an unique framework for various applications such as cardiotoxicity screening, drug discovery, disease modeling, and cell therapy. In the particular case of inherited cardiomyopathies and channelopathies, iPSC-based models prompted the study of disease mechanisms in an individual-/allele-specific manner, as well as the customization of therapeutic regimen. Herein, we will present and critically discuss the current knowledge and key experimental approaches, which qualifies patient-specific iPSCs as robust “disease-in-a-dish” models for genetic cardiomyopathies and channelopathies after 15 years of research.
Publish Date	2021-04-22 10:31
Citation	Micheu MM, Rosca AM. Patient-specific induced pluripotent stem cells as “disease-in-a-dish” models for inherited cardiomyopathies and channelopathies – 15 years of research. World J Stem Cells 2021; 13(4): 281-303
URL	https://www.wjgnet.com/1948-0210/full/v13/i4/281.htm
DOI	https://dx.doi.org/10.4252/wjsc.v13.i4.281

Full Article (PDF)	WJSC-13-281.pdf
Full Article (Word)	WJSC-13-281.docx
Manuscript File	63741-Review-FilipodiaCL.docx
Answering Reviewers	63741-Answering reviewers.pdf
Audio Core Tip	63741-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	63741-Conflict-of-interest statement.pdf
Copyright License Agreement	63741-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	63741-Language certificate.pdf
Peer-review Report	63741-Peer-review(s).pdf
Scientific Misconduct Check	63741-Scientific misconduct check.pdf
Scientific Editor Work List	63741-Scientific editor work list.pdf
CrossCheck Report	63741-CrossCheck report.pdf