Publication Name	World Journal of Gastroenterology
Manuscript ID	63885
Country	China

Received	2021-02-04 18:08
Peer-Review Started	2021-02-04 18:16
To Make the First Decision
Return for Revision	2021-07-27 23:53
Revised	2021-08-09 18:22
Second Decision	2022-01-27 03:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-01-29 06:57
Articles in Press	2022-01-29 06:57
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-01-25 02:09
Typeset the Manuscript	2022-02-22 07:29
Publish the Manuscript Online	2022-03-03 06:59

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Innate and adaptive immune escape mechanisms of hepatitis B virus
Manuscript Source	Invited Manuscript
All Author List	Hua-Jun Zhao, Yi-Fei Hu, Qiu-Ju Han and Jian Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Science Foundation for Young Scientists of China 82001687 National Major Science and Technology Project for Control and Prevention of Major Infectious Diseases 2018ZX10301401 National Postdoctoral Program for Innovative Talents BX20190192 China Postdoctoral Science Foundation 2020M672064 National Basic Research Program of China 2013CB531503
Corresponding Author	Jian Zhang, PhD, Professor, Institute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences , Shandong University, 44 Wenhua West Road, Jinan 250012, Shandong Province, China. zhangj65@sdu.edu.cn
Key Words	Hepatitis B virus; Innate immunity; Adaptive immunity; Immune tolerance; Therapeutic strategy
Core Tip	Chronic hepatitis B (CHB) infection is an international health problem. Current clinical CHB treatment strategies can partly inhibit and eliminate hepatitis B virus (HBV), but cannot achieve long-lasting immune control of the virus. Persistent CHB infection arises as a consequence of the complex interactions between HBV and the host innate and adaptive immune systems. Therefore, it is important to understand the immunological mechanisms involved in CHB infection. In this review, we detail the immune biological characteristics and escape mechanisms of HBV and discuss novel immune-based therapies.
Publish Date	2022-03-03 06:59
Citation	Zhao HJ, Hu YF, Han QJ, Zhang J. Innate and adaptive immune escape mechanisms of hepatitis B virus. World J Gastroenterol 2022; 28(9): 881-896
URL	https://www.wjgnet.com/1007-9327/full/v28/i9/881.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i9.881

Full Article (PDF)	WJG-28-881.pdf
Full Article (Word)	WJG-28-881.docx
Manuscript File	63885_Auto_Edited-YJM-Filipodia.docx
Answering Reviewers	63885-Answering reviewers.pdf
Audio Core Tip	63885-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	63885-Conflict-of-interest statement.pdf
Copyright License Agreement	63885-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	63885-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	63885-Language certificate.pdf
Peer-review Report	63885-Peer-review(s).pdf
Scientific Editor Work List	63885-Scientific editor work list.pdf