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7/23/2021 1:41:09 PM | Browse: 225 | Download: 414
Publication Name World Journal of Stem Cells
Manuscript ID 64490
Country/Territory Italy
Received
2021-02-18 13:28
Peer-Review Started
2021-02-18 13:33
To Make the First Decision
Return for Revision
2021-03-16 22:25
Revised
2021-03-25 10:58
Second Decision
2021-05-07 13:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-05-07 14:12
Articles in Press
2021-05-07 14:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-06-25 08:13
Typeset the Manuscript
2021-07-21 11:58
Publish the Manuscript Online
2021-07-23 13:30
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Immunotherapy against programmed death-1/programmed death ligand 1 in hepatocellular carcinoma: Importance of molecular variations, cellular heterogeneity, and cancer stem cells
Manuscript Source Invited Manuscript
All Author List Caecilia H C Sukowati, Korri Elvanita El-Khobar and Claudio Tiribelli
Funding Agency and Grant Number
Funding Agency Grant Number
2020 Grant of the Fondazione Umberto Veronesi, Milan, Italy (to Sukowati CHC)
Grant of the Regione Autonomo Friuli Venezia Giulia in Progetti Internazionali 2020 (DGR 2195 dd 20/12/2019) to the FIF
Corresponding Author Caecilia H C Sukowati, BSc, PhD, Senior Scientist, Centro Studi Fegato, Fondazione Italiana Fegato ONLUS, AREA Science Park Basovizza, SS14 km 163.5, Trieste 34149, Italy. caecilia.sukowati@fegato.it
Key Words Hepatocellular carcinoma; Programmed death-1; Programmed death ligand 1; Cancer stem cells; Cancer heterogeneity; Genetic variants
Core Tip Immune checkpoint inhibitors (ICIs), in particular the ICI against the programmed death-1/programmed death ligand 1 (PD-L1/PD-L1) axis, has been recently presented for the treatment of hepatocellular carcinoma (HCC). However, despite the success of anti-PD-1/PD-L1 in other cancers, a substantial proportion of HCC patients fails to respond. Here, we gather current information on biomarkers of anti-PD-1/PD-L1 treatment and the contribution of HCC heterogeneity and hepatic cancer stem cells.
Publish Date 2021-07-23 13:30
Citation Sukowati CHC, El-Khobar KE, Tiribelli C. Immunotherapy against programmed death-1/programmed death ligand 1 in hepatocellular carcinoma: Importance of molecular variations, cellular heterogeneity, and cancer stem cells. World J Stem Cells 2021; 13(7): 795-824
URL https://www.wjgnet.com/1948-0210/full/v13/i7/795.htm
DOI https://dx.doi.org/10.4252/wjsc.v13.i7.795
Full Article (PDF) WJSC-13-795.pdf
Full Article (Word) WJSC-13-795.docx
Manuscript File 64490_Auto_Edited-ZMG-Webster J KE[25378][22978]-Clear.docx
Answering Reviewers 64490-Answering reviewers.pdf
Audio Core Tip 64490-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 64490-Conflict-of-interest statement.pdf
Copyright License Agreement 64490-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 64490-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 64490-Language certificate.pdf
Peer-review Report 64490-Peer-review(s).pdf
Scientific Misconduct Check 64490-Scientific misconduct check.pdf
Scientific Editor Work List 64490-Scientific editor work list.pdf