| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Review |
| Article Title |
Cardiac stem cells: Current knowledge and future prospects
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Radwa Ali Mehanna, Marwa M Essawy, Mona A Barkat, Ashraf K Awaad, Eman H Thabet, Heba A Hamed, Hagar Elkafrawy, Nehal A Khalil, Abeer Sallam, Marwa A Kholief, Samar S Ibrahim and Ghada M Mourad |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science, Technology & Innovation Funding Authority STIFA |
28932 |
| Cardiovascular Research, Education, Prevention Foundation (CVREP) |
|
|
| Corresponding Author |
Radwa Ali Mehanna, MD, PhD, Academic Research, Associate Professor, Executive Vice President, Medical Physiology Department/Center of Excellence for Research in Regenerative Medicine and Applications, Faculty of Medicine, Alexandria University, Al Khartoum Square, Azareeta, Alexandria 21500, Egypt. radwa.mehanna@alexmed.edu.eg |
| Key Words |
Cardiac stem and progenitor cells; Cardiac stem cells’ secretome; Cardiac stem cells’ niche and metabolism; Nanotechnology; Clinical trials; Combined therapy |
| Core Tip |
With the growing evidence for the existence of regenerating cardiac stem and progenitor cells, studies to evaluate their therapeutic potential have received increasing attention. Although pre-clinical research and clinical trials have demonstrated promising results, yet the latter were often inconsistent in many aspects thus imposing the need for deeper exploration of the molecular biology and relevant pathways regulating cardiogenesis and cardiac muscle repair. This review gives an insight into cardiac stem and progenitor cells regarding their embryological origin, populations, niche, secretome, and metabolism. It overviews the current preclinical research, including medical nanotechnology, and the clinical trials generally applied for cardiac regeneration. |
| Publish Date |
2022-01-20 10:47 |
| Citation |
Mehanna RA, Essawy MM, Barkat MA, Awaad AK, Thabet EH, Hamed HA, Elkafrawy H, Khalil NA, Sallam A, Kholief MA, Ibrahim SS, Mourad GM. Cardiac stem cells: Current knowledge and future prospects. World J Stem Cells 2022; 14(1): 1-40 |
| URL |
https://www.wjgnet.com/1948-0210/full/v14/i1/1.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v14.i1.1 |
