| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Pathogenesis of autoimmune hepatitis
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Jun-Hua Fan, Geng-Feng Liu, Xiao-Dan Lv, Rui-Zhi Zeng, Ling-Ling Zhan and Xiao-Ping Lv |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81860120 |
| National Natural Science Foundation of China |
81860104 |
| Guangxi Natural Science Foundation |
2017GXNSFBA198134 |
| Guangxi Natural Science Foundation |
2017GXNSFAA198299 |
| Guangxi Natural Science Foundation |
2015GXNSFCA139024 |
| Development and Application of Medical and Health Appropriate Technology Project in Guangxi Zhuang Autonomous Region |
S2018049 |
|
| Corresponding Author |
Xiao-Ping Lv, PhD, Chairman, Chief Doctor, Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. lxxp58@hotmail.com |
| Key Words |
Autoimmune hepatitis; Genetic susceptibility; environmental factors; Immunomodulation; Drug-induced liver injury; Intestinal microbes |
| Core Tip |
Autoimmune hepatitis (AIH) has no specific clinical manifestations. AIH patients often require steroid hormones plus immunosuppressive maintenance therapy. Long-term medication may cause various adverse reactions, complications, and relapse after drug withdrawal, which imposes a heavy burden on patient's health and quality of life. Although the exact pathogenesis of AIH is still unclear, there are multiple theories, and continuous in-depth research on its pathogenesis has led to development in treatment of AIH. Genetic susceptibility, environmental factors (viruses, parasites, pets, etc.), immune system, drugs and biological agents, pregnancy and liver transplantation have been reported to be associated with AIH. |
| Publish Date |
2021-08-20 09:33 |
| Citation |
Fan JH, Liu GF, Lv XD, Zeng RZ, Zhan LL, Lv XP. Pathogenesis of autoimmune hepatitis. World J Hepatol 2021; 13(8): 879-886 |
| URL |
https://www.wjgnet.com/1948-5182/full/v13/i8/879.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v13.i8.879 |
