Publication Name	World Journal of Virology
Manuscript ID	65115
Country	Bulgaria

Received	2021-02-28 09:20
Peer-Review Started	2021-02-28 09:25
To Make the First Decision
Return for Revision	2021-05-05 21:39
Revised	2021-05-19 00:19
Second Decision	2021-06-23 12:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-06-23 13:14
Articles in Press	2021-06-23 13:14
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-07-05 03:27
Typeset the Manuscript	2021-07-12 10:36
Publish the Manuscript Online	2021-07-21 08:20

ISSN	2220-3249 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Infectious Diseases
Manuscript Type	Review
Article Title	Hypotheses and facts for genetic factors related to severe COVID-19
Manuscript Source	Invited Manuscript
All Author List	Stanislav Vasilev Kotsev, Dimitrina Miteva, Stanislava Krayselska, Martina Shopova, Maria Pishmisheva-Peleva, Spaska Angelova Stanilova and Tsvetelina Velikova
Funding Agency and Grant Number
Corresponding Author	Tsvetelina Velikova, MD, PhD, Assistant Professor, Department of Clinical Immunology, University Hospital Lozenetz, Kozyak 1 Street, Sofia 1407, Bulgaria. tsvelikova@medfac.mu-sofia.bg
Key Words	Genome-wide association studies; Severe COVID-19; SARS-CoV-2; ACE2; TLR7; ApoE; TYK2; OAS; DPP9; IFNAR2; CCR2
Core Tip	Understanding what counts to the development of severe coronavirus disease-2019 (COVID-19) can be of considerable clinical and therapeutic advantage. Severe acute respiratory syndrome coronavirus 2 infection may present with different COVID-19 manifestations, where various host genetic factors influence the viral susceptibility, immune response, disease progression, and outcomes. Genome-wide association analysis allows the identification of potential candidate genes involved in the development of severe COVID-19. Hence, it seems that genetics matters here, as well.
Publish Date	2021-07-21 08:20
Citation	Kotsev SV, Miteva D, Krayselska S, Shopova M, Pishmisheva-Peleva M, Stanilova SA, Velikova T. Hypotheses and facts for genetic factors related to severe COVID-19. World J Virol 2021; 10(4): 137-155
URL	https://www.wjgnet.com/2220-3249/full/v10/i4/137.htm
DOI	https://dx.doi.org/10.5501/wjv.v10.i4.137

Full Article (PDF)	WJV-10-137.pdf
Full Article (Word)	WJV-10-137.docx
Manuscript File	65115_Review-Filipodia.docx
Answering Reviewers	65115-Answering reviewers.pdf
Audio Core Tip	65115-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	65115-Conflict-of-interest statement.pdf
Copyright License Agreement	65115-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	65115-Language certificate.pdf
Peer-review Report	65115-Peer-review(s).pdf
Scientific Misconduct Check	65115-Scientific misconduct check.pdf
Scientific Editor Work List	65115-Scientific editor work list.pdf