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8/20/2021 5:54:13 AM | Browse: 217 | Download: 510
Publication Name World Journal of Stem Cells
Manuscript ID 65857
Country/Territory Germany
Received
2021-03-16 20:49
Peer-Review Started
2021-03-16 20:58
To Make the First Decision
Return for Revision
2021-05-05 04:55
Revised
2021-05-25 19:02
Second Decision
2021-08-06 03:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-08-06 08:15
Articles in Press
2021-08-06 08:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-08-19 01:58
Publish the Manuscript Online
2021-08-20 05:46
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Neurosciences
Manuscript Type Review
Article Title Modulating poststroke inflammatory mechanisms: Novel aspects of mesenchymal stem cells, extracellular vesicles and microglia
Manuscript Source Invited Manuscript
All Author List Wen-Qiang Xin, Wei Wei, Yong-Li Pan, Bao-Long Cui, Xin-Yu Yang, Mathias Bähr and Thorsten R Doeppner
Funding Agency and Grant Number
Corresponding Author Thorsten R Doeppner, MD, MSc, Professor, Department of Neurology, University Medical Center Göttingen, Robert-Koch-Str. 40, Göttingen 37075, Germany. thorsten.doeppner@med.uni-goettingen.de
Key Words Extracellular vesicles; Mesenchymal stem cells; Microglial activation; M2 polarization; Ischemic stroke
Core Tip Upon stroke induction, M1 microglia participate in the proinflammatory tissue response, whereas M2 microglia promote brain repair by secreting anti-inflammatory cytokines and neurotrophic factors. This review summarizes the effects of mesenchymal stem cells (MSCs) and MSC-extracellular vesicles on regulating microglial activity under ischemic stroke conditions through various signaling pathways, such as cytokines, neurotrophic factors, transcription factors, and microRNAs.
Publish Date 2021-08-20 05:46
Citation Xin WQ, Wei W, Pan YL, Cui BL, Yang XY, Bähr M, Doeppner TR. Modulating poststroke inflammatory mechanisms: Novel aspects of mesenchymal stem cells, extracellular vesicles and microglia. World J Stem Cells 2021; 13(8): 1030-1048
URL https://www.wjgnet.com/1948-0210/full/v13/i8/1030.htm
DOI https://dx.doi.org/10.4252/wjsc.v13.i8.1030
Full Article (PDF) WJSC-13-1030.pdf
Full Article (Word) WJSC-13-1030.docx
Manuscript File 65857_Auto_Edited-JPY.docx
Answering Reviewers 65857-Answering reviewers.pdf
Audio Core Tip 65857-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 65857-Conflict-of-interest statement.pdf
Copyright License Agreement 65857-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 65857-Language certificate.pdf
Peer-review Report 65857-Peer-review(s).pdf
Scientific Misconduct Check 65857-Scientific misconduct check.pdf
Scientific Editor Work List 65857-Scientific editor work list.pdf