ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Review |
Article Title |
Gut bless you: The microbiota-gut-brain axis in irritable bowel syndrome
|
Manuscript Source |
Invited Manuscript |
All Author List |
Eline Margrete Randulff Hillestad, Aina van der Meeren, Bharat Halandur Nagaraja, Ben René Bjørsvik, Noman Haleem, Alfonso Benitez-Paez, Yolanda Sanz, Trygve Hausken, Gülen Arslan Lied, Arvid Lundervold and Birgitte Berentsen |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
The Spanish Ministry of Science and Innovation |
AGL2017-88801-P |
Norwegian Research Council |
FRIMEDBIO276010 |
Helse Vest's Research Funding |
HV912243 |
ERC H2020-MSCA-IF-2019 |
895219 |
|
Corresponding Author |
Birgitte Berentsen, MSc, PhD, Associate Professor, National Center for Functional Gastrointestinal Disorders, Department of Medicine, Haukeland University Hospital, National Center for Functional Gastrointestinal Disorders, Department of Medicine, Haukeland University Hospital, Jonas Lies vei 65, 5021 Bergen, Norway , Bergen 5021, Norway. birgitte.berentsen1@helse-bergen.no |
Key Words |
Microbiota; Neurogastroenterology; Irritable bowel syndrome; Microbiota-gut-brain axis; Structural and functional magnetic resonance imaging; Machine learning; Big data analysis |
Core Tip |
Molecular biology, advanced neuroimaging and computer science is emerging to transform our understanding of the role of gut microbiota in irritable bowel syndrome (IBS). Herein, we provide an overview and discuss the role of gut microbiota in IBS, the clinical microbiota-altering interventions the low FODMAP diet and fecal microbiota transplantation, the role of brain-imaging and gut microbiota analyses, the importance of method selection, metadata, perspectives for improving microbiota role predictions, and big data analysis, in the seeking of understanding IBS pathology. |
Publish Date |
2022-01-22 06:41 |
Citation |
Hillestad EMR, van der Meeren A, Nagaraja BH, Bjørsvik BR, Haleem N, Benitez-Paez A, Sanz Y, Hausken T, Lied GA, Lundervold A, Berentsen B. Gut bless you: The microbiota-gut-brain axis in irritable bowel syndrome. World J Gastroenterol 2022; 28(4): 412-431 |
URL |
https://www.wjgnet.com/1007-9327/full/v28/i4/412.htm |
DOI |
https://dx.doi.org/10.3748/wjg.v28.i4.412 |