Publication Name	World Journal of Nephrology
Manuscript ID	66103
Country	Japan

Received	2021-03-21 03:52
Peer-Review Started	2021-03-21 03:55
To Make the First Decision
Return for Revision	2021-05-06 02:20
Revised	2021-05-15 01:14
Second Decision	2021-08-10 03:00
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-08-10 07:08
Articles in Press	2021-08-10 07:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-09-21 12:15
Publish the Manuscript Online	2021-09-26 03:15

ISSN	2220-6124 (online)
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Category	Critical Care Medicine
Manuscript Type	Minireviews
Article Title	Trends in pediatric nephrotic syndrome
Manuscript Source	Invited Manuscript
All Author List	Hiroshi Tamura
Funding Agency and Grant Number
Corresponding Author	Hiroshi Tamura, MD, PhD, Assistant Professor, Department of Pediatrics, Kumamoto University, 1-1-1 Honjo, Chuo-ku, kumamoto 8608556, Japan. bohm1905ht@kuh.kumamoto-u.ac.jp
Key Words	Nephrotic syndrome; Gene; Immunity; Viral infection; Children
Core Tip	There is no doubt that some vascular hyperpermeability factor is involved in the incidence of proteinuria in idiopathic nephrotic syndrome (INS). However, no etiological molecule has been identified in INS as a factor for increasing the permeability of renal glomerular capillaries with reproducibility and clinical consistency. In addition, since the onset is sometimes observed in the family, there is high incidence of INS in East Asian children and there is the association of steroid-sensitive NS in childhood in Japan with the HLA-DR/DQ region, it is highly possible that some genetic factors are involved in the onset of NS. In our opinion, INS is a multifactorial disease in which immunological stimuli, trigger the production of substances that impair podocytes, resulting in dysfunction of the slit membrane and cause proteinuria.
Publish Date	2021-09-26 03:15
Citation	Tamura H. Trends in pediatric nephrotic syndrome. World J Nephrol 2021; 10(5): 88-100
URL	https://www.wjgnet.com/2220-6124/full/v10/i5/88.htm
DOI	https://dx.doi.org/10.5527/wjn.v10.i5.88

Full Article (PDF)	WJN-10-88.pdf
Full Article (Word)	WJN-10-88.docx
Manuscript File	66103_Auto_Edited-JPY.docx
Answering Reviewers	66103-Answering reviewers.pdf
Audio Core Tip	66103-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	66103-Conflict-of-interest statement.pdf
Copyright License Agreement	66103-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	66103-Language certificate.pdf
Peer-review Report	66103-Peer-review(s).pdf
Scientific Misconduct Check	66103-Bing-Fan JR-2.png
Scientific Misconduct Check	66103-Scientific misconduct check.pdf
Scientific Editor Work List	66103-Scientific editor work list.pdf