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10/20/2021 7:43:46 AM | Browse: 291 | Download: 474
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Received |
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2021-04-13 02:40 |
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Peer-Review Started |
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2021-04-01 02:59 |
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To Make the First Decision |
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Return for Revision |
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2021-06-24 18:29 |
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Revised |
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2021-07-02 09:32 |
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Second Decision |
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2021-07-30 03:30 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2021-07-30 08:56 |
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Articles in Press |
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2021-07-30 08:56 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-08-09 20:34 |
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Typeset the Manuscript |
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2021-10-18 05:47 |
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Publish the Manuscript Online |
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2021-10-20 07:18 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Cold exposure and capsaicin promote 1,2-dimethylhyrazine-induced colon carcinogenesis in rats correlates with extracellular matrix remodeling
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing-Chun Qin, Wei-Tao Yu, Hui-Xuan Li, Yu-Qi Liang, Fei-Fei Nong and Bin Wen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81673944 |
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| Corresponding Author |
Bin Wen, PhD, Academic Research, Full Professor, Institute of Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, No. 12 Airport Road, Guangdong 530001, Guangdong Province, China. wenbin@gzucm.edu.cn |
| Key Words |
Colon cancer; Cold exposure; Capsaicin; Extracellular matrix remodeling; Extracellular matrix enzymes |
| Core Tip |
In this study, we discovered that remodeling of extracellular matrix (ECM) plays an important role in the progression of colorectal cancer (CRC). These results suggest that increased stiffness of colonic tissue and the remodeling of ECM mediated by ECM enzymes resulting from cold and capsaicin exposure predisposing an environment suitable for CRC development and progression. To target ECM in CRC tumor tissue could represent a novel potential therapeutic strategy. |
| Publish Date |
2021-10-20 07:18 |
| Citation |
Qin JC, Yu WT, Li HX, Liang YQ, Nong FF, Wen B. Cold exposure and capsaicin promote 1,2-dimethylhyrazine-induced colon carcinogenesis in rats correlates with extracellular matrix remodeling. World J Gastroenterol 2021; 27(39): 6615-6630 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i39/6615.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i39.6615 |
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