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9/29/2021 11:17:38 AM | Browse: 72 | Download: 128
Publication Name World Journal of Gastroenterology
Manuscript ID 66883
Country/Territory Taiwan
2021-04-08 11:05
Peer-Review Started
2021-04-08 11:08
To Make the First Decision
Return for Revision
2021-06-26 03:31
2021-07-06 02:00
Second Decision
2021-09-01 02:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-09-01 09:32
Articles in Press
2021-09-01 09:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-09-27 01:24
Publish the Manuscript Online
2021-09-29 11:12
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Retrospective Cohort Study
Article Title Hepatitis B virus persistent infection-related single nucleotide polymorphisms in HLA regions are associated with viral load in hepatoma families
Manuscript Source Invited Manuscript
All Author List Ai-Ru Hsieh, Cathy S J Fann, Hung-Chun Lin, Jennifer Tai, Sen-Yung Hsieh and Dar-In Tai
Funding Agency and Grant Number
Funding Agency Grant Number
Chang Gung Memorial Hospital CMRPG3C0701
National Science Council NSC101-2314-B-182A-025-MY3
National Science Council MOST 107-2314-B-039-059
Corresponding Author Dar-In Tai, MD, PhD, Professor, Division of Hepatology, Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Medical Center, No. 5 Fuxing Street, Guishan District, Taoyuan 33305, Taiwan. tai48978@cgmh.org.tw
Key Words Generalized estimating equation; Genetic polymorphism; Genome-wide association study; Hepatitis B surface antigen; Hepatitis B virus; Replication
Core Tip Hepatitis B virus (HBV)-related single nucleotide polymorphisms (SNPs) have been identified in East Asians. We evaluated five SNPs and nongenetic factors associated with HBV infection in a hepatocellular carcinoma family cohort. The factors were correlated with hepatitis B surface antigen (HBsAg) in the first-stage and with HBV viral load in the second-stage. The SNPs, sex, generation, and index case HBsAg contributed to persistent HBV infection. Neonatal tolerance and SNPs in the HLA loci were both independently associated with persistent HBV infection. A prolonged HBV replication phase in parents could be the main mechanism of persistent HBV infection in children in East Asia.
Publish Date 2021-09-29 11:12
Citation Hsieh AR, Fann CSJ, Lin HC, Tai J, Hsieh SY, Tai DI. Hepatitis B virus persistent infection-related single nucleotide polymorphisms in HLA regions are associated with viral load in hepatoma families. World J Gastroenterol 2021; 27(37): 6262-6276
URL https://www.wjgnet.com/1007-9327/full/v27/i37/6262.htm
DOI https://dx.doi.org/10.3748/wjg.v27.i37.6262
Full Article (PDF) WJG-27-6262.pdf
Full Article (Word) WJG-27-6262.docx
Manuscript File 66883_Auto_Edited-JLW.docx
Answering Reviewers 66883-Answering reviewers.pdf
Audio Core Tip 66883-Audio core tip.mp3
Biostatistics Review Certificate 66883-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 66883-Conflict-of-interest statement.pdf
Copyright License Agreement 66883-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 66883-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 66883-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 66883-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 66883-Language certificate.pdf
Peer-review Report 66883-Peer-review(s).pdf
Scientific Misconduct Check 66883-Scientific misconduct check.pdf
Scientific Editor Work List 66883-Scientific editor work list.pdf