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12/17/2021 9:17:58 AM | Browse: 290 | Download: 550
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Received |
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2021-04-18 12:37 |
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Peer-Review Started |
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2021-04-18 12:39 |
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To Make the First Decision |
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Return for Revision |
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2021-06-13 15:26 |
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Revised |
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2021-06-15 21:39 |
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Second Decision |
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2021-09-17 03:30 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2021-09-19 08:46 |
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Articles in Press |
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2021-09-19 08:46 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2021-11-30 17:20 |
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Typeset the Manuscript |
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2021-12-13 03:13 |
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Publish the Manuscript Online |
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2021-12-17 08:56 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Multiparameter magnetic resonance imaging of liver fibrosis in a bile duct ligation mouse model
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jia-Yi Liu, Zhu-Yuan Ding, Zi-Yi Zhou, Sheng-Zhen Dai, Jie Zhang, Hao Li, Qiu Du, Ye-Yu Cai, Quan-Liang Shang, Yong-Heng Luo and En-Hua Xiao |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Provincial Natural Science Foundation of Hunan |
2019JJ40444 |
| Provincial Natural Science Foundation of Hunan |
2021JJ30945 |
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| Corresponding Author |
Yong-Heng Luo, PhD, Attending Doctor, Department of Radiology, Second Xiangya Hospital of Central South University, No. 139 Renming Middle Road, Changsha 410011, Hunan Province, China. luoyongheng@csu.edu.cn |
| Key Words |
Liver; Fibrosis; Magnetic resonance imaging; Pathology; Animal model; Bile duct ligation |
| Core Tip |
Magnetic resonance imaging (MRI) is promising for the noninvasive assessment of liver fibrosis, but the utility of multiparameter MRI in the bile duct ligation (BDL) mouse model has not been assessed. We established an experimental BDL mouse model that mimics various aspects of cholestatic fibrosis and evaluated the potential of multiparameter MRI for the assessment of cholestatic fibrosis. We found that the BDL mouse model induces a complex cascade of changes that can be observed clearly on MRI images. The T2 and △T1 values are well correlated with the hepatic fibrosis rate and may allow for the detection of cholestatic fibrosis. |
| Publish Date |
2021-12-17 08:56 |
| Citation |
Liu JY, Ding ZY, Zhou ZY, Dai SZ, Zhang J, Li H, Du Q, Cai YY, Shang QL, Luo YH, Xiao EH. Multiparameter magnetic resonance imaging of liver fibrosis in a bile duct ligation mouse model. World J Gastroenterol 2021; 27(47): 8156-8165 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i47/8156.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i47.8156 |
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