Publication Name	World Journal of Immunology
Manuscript ID	68033
Country	Bulgaria

Received	2021-05-09 20:09
Peer-Review Started	2021-05-09 20:12
To Make the First Decision
Return for Revision	2021-07-27 06:29
Revised	2021-08-16 12:28
Second Decision	2021-10-15 06:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-10-15 08:53
Articles in Press	2021-10-15 08:53
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-09-30 23:41
Typeset the Manuscript	2021-10-26 07:03
Publish the Manuscript Online	2021-10-28 03:02

ISSN	2219-2824 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Transplantation
Manuscript Type	Opinion Review
Article Title	Interactions between human microbiome, liver diseases, and immunosuppression after liver transplant
Manuscript Source	Unsolicited Manuscript
All Author List	Milena Peruhova, Monika Peshevska-Sekulovska and Tsvetelina Velikova
Funding Agency and Grant Number
Corresponding Author	Milena Peruhova, MD, Assistant Professor, Chief Doctor, Department of Gastroenterology, University Hospital Lozenetz, Kozyak 1 str., Sofia 1407, Bulgaria. mperuhova@gmail.com
Key Words	Liver transplantation; De novo malignancy; Immunosuppressive therapy; Calcineurin inhibitors; Tacrolimus; Cyclosporine; Microbiome; Carcinogenesis; Immune tolerance
Core Tip	It was estimated that liver transplant recipients have a higher risk of developing de novo malignancy (DNM) compared to the general population. Immunosuppressive (IS) therapy used after liver transplantation (LT) is one of the substantial risk factors for the development of DNM. Tumorigenesis and tumor growth in LT patients are linked with the length of IS therapy's administration and intensity. Recent data showed that the microbiota could significantly affect the survival and acceptance of transplanted allographs. This once again indicates the incredibly complex interaction between the immune system and microbiome in the settings of LT and raises the possible strategies to induce immunotolerance and reduce the complications such as DNM.
Publish Date	2021-10-28 03:02
Citation	Peruhova M, Peshevska-Sekulovska M, Velikova T. Interactions between human microbiome, liver diseases, and immunosuppression after liver transplant. World J Immunol 2021; 11(2): 11-16
URL	https://www.wjgnet.com/2219-2824/full/v11/i2/11.htm
DOI	https://dx.doi.org/10.5411/wji.v11.i2.11

Full Article (PDF)	WJI-11-11.pdf
Full Article (Word)	WJI-11-11.docx
Manuscript File	68033_Auto_Edited-JRF-FilipodiaCL.docx
Answering Reviewers	68033-Answering reviewers.pdf
Audio Core Tip	68033-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	68033-Conflict-of-interest statement.pdf
Copyright License Agreement	68033-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	68033-Language certificate.pdf
Peer-review Report	68033-Peer-review(s).pdf
Scientific Misconduct Check	68033-Bing-Gong ZM-1.png
Scientific Misconduct Check	68033-Bing-Fan JR-2.png
Scientific Editor Work List	68033-Scientific editor work list.pdf