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11/24/2021 1:06:49 PM | Browse: 31 | Download: 13
Publication Name World Journal of Hepatology
Manuscript ID 69046
Country/Territory United States
2021-06-14 17:35
Peer-Review Started
2021-06-14 17:40
To Make the First Decision
Return for Revision
2021-07-27 02:32
2021-08-08 01:47
Second Decision
2021-09-18 03:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-09-19 09:03
Articles in Press
2021-09-19 09:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-11-19 00:42
Publish the Manuscript Online
2021-11-24 09:54
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Retrospective Cohort Study
Article Title Nonalcoholic fatty liver disease is associated with worse intestinal complications in patients hospitalized for Clostridioides difficile infection
Manuscript Source Unsolicited Manuscript
All Author List Yi Jiang, Salil Chowdhury, Bing-Hong Xu, Mohamad Aghaie Meybodi, Konstantinos Damiris, Samanthika Devalaraju and Nikolaos Pyrsopoulos
Funding Agency and Grant Number
Corresponding Author Nikolaos Pyrsopoulos, FAASLD, AGAF, FACG, MD, PhD, Director, Professor, Department of Medicine, Gastroenterology and Hepatology, Rutgers New Jersey Medical School, 185 S. Orange Avenue, Medical Science Building H-536, Newark, NJ 07101, United States. pyrsopni@njms.rutgers.edu
Key Words Nonalcoholic fatty liver disease; Clostridioides difficile infection; Gut microbiota; Intestinal complications; Alcoholic liver disease; Viral liver disease
Core Tip This study demonstrated that patients hospitalized with Clostridioides difficile infection (CDI) and coexisting nonalcoholic fatty liver disease (NAFLD) had more favorable overall outcomes but higher rates of intestinal complications when compared to those with alcoholic liver disease and viral liver disease individually, which suggests altering gut microbiota may play an essential role in the pathogenesis of both CDI and NAFLD. NAFLD-associated metabolic syndrome may contribute significantly to gut dysbiosis and increase risk for CDI and its complications. This study provides potential directions for future prospective clinical research to identify the clinical meaningfulness of interactions between the gut microbiota, gut immunity and systemic inflammation.
Publish Date 2021-11-24 09:54
Citation Jiang Y, Chowdhury S, Xu BH, Meybodi MA, Damiris K, Devalaraju S, Pyrsopoulos N. Nonalcoholic fatty liver disease is associated with worse intestinal complications in patients hospitalized for Clostridioides difficile infection. World J Hepatol 2021; 13(11): 1777-1790
URL https://www.wjgnet.com/1948-5182/full/v13/i11/1777.htm
DOI https://dx.doi.org/10.4254/wjh.v13.i11.1777
Full Article (PDF) WJH-13-1777.pdf
Full Article (Word) WJH-13-1777.docx
Manuscript File 69046_Auto_Edited.docx
Answering Reviewers 69046-Answering reviewers.pdf
Audio Core Tip 69046-Audio core tip.mp3
Biostatistics Review Certificate 69046-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 69046-Conflict-of-interest statement.pdf
Copyright License Agreement 69046-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 69046-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 69046-Institutional review board statement.pdf
Supplementary Material 69046-Supplementary material.pdf
Peer-review Report 69046-Peer-review(s).pdf
Scientific Editor Work List 69046-Scientific editor work list.pdf