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1/22/2022 7:40:54 AM | Browse: 474 | Download: 1022
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Received |
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2021-08-08 07:58 |
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Peer-Review Started |
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2021-08-08 08:03 |
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First Decision by Editorial Office Director |
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2021-11-07 20:50 |
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Return for Revision |
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2021-11-07 20:50 |
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Revised |
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2021-11-15 15:15 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-01-06 03:31 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-01-06 18:45 |
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Articles in Press |
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2022-01-06 18:45 |
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Edit the Manuscript by Language Editor |
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2022-01-02 01:18 |
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Typeset the Manuscript |
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2022-01-18 03:06 |
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Publish the Manuscript Online |
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2022-01-22 06:41 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Knockdown of DEAD-box 51 inhibits tumor growth of esophageal squamous cell carcinoma via the PI3K/AKT pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Dong-Xin Hu, Qi-Feng Sun, Lin Xu, Hong-Da Lu, Fan Zhang, Zhen-Miao Li and Ming-Yan Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Shandong Province |
ZR2020QH194 |
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| Corresponding Author |
Ming-Yan Zhang, PhD, Chief Physician, Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250000, Shandong Province, China. zhangmingyan@sdfmu.edu.cn |
| Key Words |
Esophageal squamous cell carcinoma; DDX51; PI3K/AKT pathway; Tumor growth; Therapeutic target |
| Core Tip |
Our study revealed that DEAD-box helicase 51 was upregulated in esophageal squamous cell carcinoma (ESCC) tumor tissues and promoted tumor proliferation and development by upregulating the phosphorylation of phosphoinositide 3-kinase/AKT pathway members. These data extend our knowledge of the function and molecular mechanism of the DEAD-box family in tumor biology and provide a potential therapeutic target for ESCC treatment. |
| Publish Date |
2022-01-22 06:41 |
| Citation |
Hu DX, Sun QF, Xu L, Lu HD, Zhang F, Li ZM, Zhang MY. Knockdown of DDX51 inhibits tumor growth of esophageal squamous cell carcinoma via the PI3K/AKT pathway. World J Gastroenterol 2022; 28(4): 464-478 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i4/464.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i4.464 |
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