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6/16/2022 1:22:12 PM | Browse: 47 | Download: 80
Publication Name World Journal of Gastroenterology
Manuscript ID 71392
Country/Territory Australia
Received
2021-09-14 02:19
Peer-Review Started
2021-09-14 02:21
To Make the First Decision
Return for Revision
2021-11-07 18:06
Revised
2021-11-21 04:04
Second Decision
2022-05-05 03:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-05-07 00:39
Articles in Press
2022-05-07 00:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-05-25 08:28
Publish the Manuscript Online
2022-06-16 13:07
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Retrospective Study
Article Title Higher infliximab and adalimumab trough levels are associated with fistula healing in patients with fistulising perianal Crohn’s disease
Manuscript Source Unsolicited Manuscript
All Author List Bonita Gu, Kavya Venkatesh, Astrid-Jane Williams, Watson Ng, Crispin Corte, Ali Gholamrezaei, Simon Ghaly, Wei Xuan, Sudarshan Paramsothy and Susan Connor
Funding Agency and Grant Number
Corresponding Author Bonita Gu, MD, Doctor, South Western Sydney Clinical School, University of New South Wales, Goulburn St, Liverpool, Sydney 2170, New South Wales, Australia. bonita.gu@health.nsw.gov.au
Key Words Crohn’s disease; Perianal disorders; Biologics; Inflammatory bowel disease
Core Tip This multicentre retrospective study demonstrated a significant association between both infliximab and adalimumab trough levels with fistula healing, with higher levels associated with increased healing rates. Higher tertiles of both infliximab and adalimumab levels were associated with a higher proportion of patients achieving fistula healing. Fistula healing, defined as cessation of fistula drainage, is a clinically relevant endpoint that impacts on patient quality of life. Our results support dose-escalation of both infliximab and adalimumab in non-responders, targeting higher levels to achieve fistula healing prior to changing biologic therapy. Importantly, this study is the largest study to date assessing the relationship between adalimumab trough levels and clinical fistula healing.
Publish Date 2022-06-16 13:07
Citation Gu B, Venkatesh K, Williams AJ, Ng W, Corte C, Gholamrezaei A, Ghaly S, Xuan W, Paramsothy S, Connor S. Higher infliximab and adalimumab trough levels are associated with fistula healing in patients with fistulising perianal Crohn’s disease. World J Gastroenterol 2022; 28(23): 2597-2608
URL https://www.wjgnet.com/1007-9327/full/v28/i23/2597.htm
DOI https://dx.doi.org/10.3748/wjg.v28.i23.2597
Full Article (PDF) WJG-28-2597.pdf
Full Article (Word) WJG-28-2597.docx
Manuscript File 71392_Auto_Edited.docx
Answering Reviewers 71392-Answering reviewers.pdf
Audio Core Tip 71392-Audio core tip.mp3
Biostatistics Review Certificate 71392-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 71392-Conflict-of-interest statement.pdf
Copyright License Agreement 71392-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 71392-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 71392-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 71392-Language certificate.pdf
Peer-review Report 71392-Peer-review(s).pdf
Scientific Misconduct Check 71392-Bing-Wang JJ-2.png
Scientific Editor Work List 71392-Scientific editor work list.pdf