| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Dynamics of cytokines predicts risk of hepatocellular carcinoma among chronic hepatitis C patients after viral eradication
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ming-Ying Lu, Ming‑Lun Yeh, Ching‑I Huang, Shu-Chi Wang, Yi‑Shan Tsai, Pei-Chien Tsai, Yu‑Min Ko, Ching‑Chih Lin, Kuan‑Yu Chen, Yu‑Ju Wei, Po‑Yao Hsu, Cheng‑Ting Hsu, Tyng‑Yuan Jang, Ta‑Wei Liu, Po‑Cheng Liang, Ming‑Yen Hsieh, Zu‑Yau Lin, Shinn-Cherng Chen, Chung-Feng Huang, Jee-Fu Huang, Chia-Yen Dai, Wan-Long Chuang and Ming-Lung Yu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Kaohsiung Medical University and Kaohsiung Medical University Hospital (KMU-KMUH Co-Project of Key Research) |
KMU-DK107004 |
|
| Corresponding Author |
Ming-Lung Yu, MD, PhD, Chief Doctor, Full Professor, Hepatitis Center and Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, No. 100 Shih-Chuan 1st Road, Sanmin District, Kaohsiung 80708, Taiwan. fish6069@gmail.com |
| Key Words |
Hepatitis C virus; Hepatocellular carcinoma; Sustained virologic response; Tumor necrosis factor-α; Tumor necrosis factor-like weak inducer of apoptosis; Cytokine |
| Core Tip |
Successful hepatitis C virus (HCV) eradication does not eliminate hepatocellular carcinoma (HCC) development. Clearance of HCV by antiviral agents results in host immune modification, which might interfere with immune-mediated cancer surveillance. We attempted to identify immune biomarkers to predict HCC occurrence after antiviral therapy. The dynamics of serum tumor necrosis factor-α (TNF-α) and TNF-like weak inducer of apoptosis were associated with HCC occurrence after HCV clearance. We established a predictive model to assess the risk of HCC among HCV patients after HCV eradication. Our findings provide a clue for the pathogenesis of hepatocarcinogenesis and a strategy for HCC surveillance based on risk stratification. |
| Publish Date |
2021-12-31 12:21 |
| Citation |
Lu MY, Yeh ML, Huang CI, Wang SC, Tsai YS, Tsai PC, Ko YM, Lin CC, Chen KY, Wei YJ, Hsu PY, Hsu CT, Jang TY, Liu TW, Liang PC, Hsieh MY, Lin ZY, Chen SC, Huang CF, Huang JF, Dai CY, Chuang WL, Yu ML. Dynamics of cytokines predicts risk of hepatocellular carcinoma among chronic hepatitis C patients after viral eradication. World J Gastroenterol 2022; 28(1): 140-153 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i1/140.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i1.140 |
