Publication Name	World Journal of Gastroenterology
Manuscript ID	72107
Country	United States

Received	2021-10-04 21:23
Peer-Review Started	2021-10-04 21:25
To Make the First Decision
Return for Revision	2021-10-20 06:49
Revised	2021-11-26 05:49
Second Decision	2021-12-31 03:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2021-12-31 21:55
Articles in Press	2021-12-31 21:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-01-05 07:28
Publish the Manuscript Online	2022-01-11 08:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Update on the applications and limitations of alpha-fetoprotein for hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Hira Hanif, Mukarram Jamat Ali, Ammu T Susheela, Iman Waheed Khan, Maria Alejandra Luna-Cuadros, Muzammil Muhammad Khan and Daryl Tan-Yeung Lau
Funding Agency and Grant Number
Corresponding Author	Daryl Tan-Yeung Lau, MD, MSc, Associate Professor, Liver Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 110 Francis St. Liver Research Center, Suite 4A, Boston, MA 02215 , United States. dlau@bidmc.harvard.edu
Key Words	Alpha-fetoprotein; Hepatocellular carcinoma; Alpha-fetoprotein-L3; Cirrhosis; Tumor markers; Hereditary persistence of alpha-fetoprotein
Core Tip	Alpha-fetoprotein has been used commonly as a biomarker for hepatocellular carcinoma (HCC) surveillance. Its sensitivity and specificity can be affected by the assay methods, patient characteristics and severity of the underlying liver conditions. Combination with other novel markers has shown promising results. Algorithms integrating these serum markers with noninvasive diagnostic imaging modalities are essential for the accurate and timely diagnosis of HCC.
Publish Date	2022-01-11 08:34
Citation	Hanif H, Ali MJ, Susheela AT, Khan IW, Luna-Cuadros MA, Khan MM, Lau DTY. Update on the applications and limitations of alpha-fetoprotein for hepatocellular carcinoma. World J Gastroenterol 2022; 28(2): 216-229
URL	https://www.wjgnet.com/1007-9327/full/v28/i2/216.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i2.216

Full Article (PDF)	WJG-28-216.pdf
Full Article (Word)	WJG-28-216.docx
Manuscript File	72107_Auto_Edited.docx
Answering Reviewers	72107-Answering reviewers.pdf
Audio Core Tip	72107-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	72107-Conflict-of-interest statement.pdf
Copyright License Agreement	72107-Copyright license agreement.pdf
Peer-review Report	72107-Peer-review(s).pdf
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Scientific Editor Work List	72107-Scientific editor work list.pdf
CrossCheck Report	72107-CrossCheck report.pdf
CrossCheck Report	72107-CrossCheck.png