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5/19/2022 3:37:15 AM | Browse: 207 | Download: 432
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Received |
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2021-10-19 14:19 |
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2021-10-19 14:21 |
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2022-01-18 01:14 |
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2022-02-05 10:55 |
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2022-03-22 06:37 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2022-03-27 06:30 |
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Articles in Press |
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2022-03-27 06:30 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-04-15 03:00 |
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Publish the Manuscript Online |
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2022-05-19 00:49 |
| ISSN |
2222-0682 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Methodology |
| Manuscript Type |
Minireviews |
| Article Title |
Network meta-analyses: Methodological prerequisites and clinical usefulness
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Savvas Ilias Christofilos, Konstantinos Tsikopoulos, Alexios Tsikopoulos, Dimitrios Kitridis, Konstantinos Sidiropoulos, Panagiotis Nikolaos Stoikos and Venu Kavarthapu |
| Funding Agency and Grant Number |
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| Corresponding Author |
Savvas Ilias Christofilos, MD, Doctor, Genetics, Evolution, and Environment, University College London, Gower street , London WC1E 6BT, United Kingdom, United Kingdom. savvaschristofilos@gmail.com |
| Key Words |
Network meta-analysis; Quality of evidence; Evidence-based medicine; Systematic reviews |
| Core Tip |
Systematic reviews with or without meta-analyses provide the highest quality of evidence, thus lying on the top of evidence-based medicine hierarchy. However, pair-wise meta-analyses present the inherent limitation of exclusively comparing direct evidence. By contrast, Network Meta-Analyses (NMAs) also consider indirect evidence, thereby offering additional useful information. Conducting an NMA, however, has certain requirements such as assuming that transitivity across the included studies exists. What is more, maintaining sufficient statistical power in the analyses is crucial. In addition, performing head-to-head statistical comparisons before setting up networks of interventions is a prerequisite for a methodologically sound NMA, and selecting not only positive but also negative outcomes is required. Lastly, implementing quality appraisal systems to grade the level of evidence is highly recommended. Should all the above criteria be fulfilled, then accurate clinical conclusions can be drawn from an NMA. |
| Publish Date |
2022-05-19 00:49 |
| Citation |
Christofilos SI, Tsikopoulos K, Tsikopoulos A, Kitridis D, Sidiropoulos K, Stoikos PN, Kavarthapu V. Network meta-analyses: Methodological prerequisites and clinical usefulness. World J Methodol 2022; 12(3): 92-98 |
| URL |
https://www.wjgnet.com/2222-0682/full/v12/i3/92.htm |
| DOI |
https://dx.doi.org/10.5662/wjm.v12.i3.92 |
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