Publication Name	World Journal of Cardiology
Manuscript ID	73838
Country	Australia

Received	2021-12-05 11:11
Peer-Review Started	2021-12-05 11:13
To Make the First Decision
Return for Revision	2022-01-25 08:42
Revised	2022-02-09 02:02
Second Decision	2022-03-25 06:32
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-03-27 06:19
Articles in Press	2022-03-27 06:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-04-11 09:32
Publish the Manuscript Online	2022-04-19 03:18

ISSN	1949-8462 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Meta-Analysis
Article Title	Effect of preoperative renin-angiotensin system blockade on vasoplegia after cardiac surgery: A systematic review with meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Jean Jacques Noubiap, Brice Nouthe, Ying Tung Sia and Marco Spaziano
Funding Agency and Grant Number
Corresponding Author	Jean Jacques Noubiap, MD, MSc, Academic Research, Senior Editor, Statistician, Centre for Heart Rhythm Disorders, The University of Adelaide, Port Road, Adelaide 5000, South Australia, Australia. noubiapjj@yahoo.fr
Key Words	Vasoplegia; Cardiac surgery; Coronary artery bypass graft; Angiotensin converting enzyme inhibitors
Core Tip	Vasoplegia is a common complication of cardiac surgery but its causal relationship with preoperative use of renin angiotensin system blockers, mainly angiotensin converting enzyme inhibitors (ACEIs), is still debated. The meta-analysis of observational studies suggests that preoperative continuation of ACEIs is associated with an increased risk of vasoplegia and of the use of inotropic support postoperatively. However, these associations were not observed in two included randomized controlled trials with limited power. These findings support the potential benefit of holding ACEIs prior to cardiac surgery to reduce the risk of vasoplegia and associated adverse outcomes. However, well-powered randomized controlled trials using a consensus definition of vasoplegia are still needed to properly assess management strategies of RAS blockers in the perioperative setting.
Publish Date	2022-04-19 03:18
Citation	Noubiap JJ, Nouthe B, Sia YT, Spaziano M. Effect of preoperative renin-angiotensin system blockade on vasoplegia after cardiac surgery: A systematic review with meta-analysis. World J Cardiol 2022; 14(4): 250-259
URL	https://www.wjgnet.com/1949-8462/full/v14/i4/250.htm
DOI	https://dx.doi.org/10.4330/wjc.v14.i4.250

Full Article (PDF)	WJC-14-250.pdf
Full Article (Word)	WJC-14-250.docx
Manuscript File	73838_Auto_Edited-YJM.docx
Answering Reviewers	73838-Answering reviewers.pdf
Audio Core Tip	73838-Audio core tip.ogg
Biostatistics Review Certificate	73838-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	73838-Conflict-of-interest statement.pdf
Copyright License Agreement	73838-Copyright license agreement.pdf
Supplementary Material	73838-Supplementary material.pdf
Peer-review Report	73838-Peer-review(s).pdf
Scientific Editor Work List	73838-Scientific editor work list.pdf
CrossCheck Report	73838-CrossCheck report.pdf