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6/16/2022 1:22:12 PM | Browse: 208 | Download: 392
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Received |
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2022-01-05 05:34 |
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Peer-Review Started |
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2022-01-05 05:36 |
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To Make the First Decision |
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Return for Revision |
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2022-03-09 05:59 |
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Revised |
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2022-03-23 09:00 |
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Second Decision |
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2022-04-28 03:28 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2022-04-28 20:46 |
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Articles in Press |
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2022-04-28 20:46 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-06-13 02:32 |
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Publish the Manuscript Online |
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2022-06-16 13:07 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Family with sequence similarity 134 member B-mediated reticulophagy ameliorates hepatocyte apoptosis induced by dithiothreitol
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Xin Guo, Bing Han, Ting Yang, Yu-Si Chen, Yi Yang, Jia-Yao Li, Qin Yang and Ru-Jia Xie |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81560105 |
| Science and Technology Foundation of Guizhou Province |
Qiankehe Jichu-ZK[2021]365 |
| Science and Technology Foundation of Guizhou Province |
Qiankehe Pingtai Rencai[2019]5801 |
| National Natural Science Foundation Cultivation Project of Guizhou Medical University |
20NSP016 |
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| Corresponding Author |
Ru-Jia Xie, MD, Academic Research, Department of Pathophysiology, College of Basic Medical Sciences, Guizhou Medical University, Dongqing Road, Guiyang 550025, Guizhou Province, China. 592153968@qq.com |
| Key Words |
Hepatocytes; Reticulophagy; Family with sequence similarity 134 member B; Apoptosis; Endoplasmic reticulum stress; Endoplasmic reticulum homeostasis |
| Core Tip |
We show that family with sequence similarity 134 member B (FAM134B)-mediated reticulophagy maintains the endoplasmic reticulum (ER) homeostasis in ER-stressed hepatocytes via the clearance of damaged ER fragments. Thereby FAM134B-mediated reticulophagy ameliorates dithiothreitol-induced hepatocyte apoptosis. Our findings provide emerging evidence of the prominence of ER-phagy in ER stress-related hepatocyte apoptosis. FAM134B may represent a potential therapeutic target for liver disease treatment. |
| Publish Date |
2022-06-16 13:07 |
| Citation |
Guo YX, Han B, Yang T, Chen YS, Yang Y, Li JY, Yang Q, Xie RJ. Family with sequence similarity 134 member B-mediated reticulophagy ameliorates hepatocyte apoptosis induced by dithiothreitol. World J Gastroenterol 2022; 28(23): 2569-2581 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i23/2569.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i23.2569 |
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