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6/16/2022 1:22:12 PM | Browse: 35 | Download: 76
Publication Name World Journal of Gastroenterology
Manuscript ID 74751
Country/Territory China
Received
2022-01-05 05:34
Peer-Review Started
2022-01-05 05:36
To Make the First Decision
Return for Revision
2022-03-09 05:59
Revised
2022-03-23 09:00
Second Decision
2022-04-28 03:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-04-28 20:46
Articles in Press
2022-04-28 20:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-06-13 02:32
Publish the Manuscript Online
2022-06-16 13:07
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Family with sequence similarity 134 member B-mediated reticulophagy ameliorates hepatocyte apoptosis induced by dithiothreitol
Manuscript Source Unsolicited Manuscript
All Author List Yi-Xin Guo, Bing Han, Ting Yang, Yu-Si Chen, Yi Yang, Jia-Yao Li, Qin Yang and Ru-Jia Xie
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81560105
Science and Technology Foundation of Guizhou Province Qiankehe Jichu-ZK[2021]365
Science and Technology Foundation of Guizhou Province Qiankehe Pingtai Rencai[2019]5801
National Natural Science Foundation Cultivation Project of Guizhou Medical University 20NSP016
Corresponding Author Ru-Jia Xie, MD, Academic Research, Department of Pathophysiology, College of Basic Medical Sciences, Guizhou Medical University, Dongqing Road, Guiyang 550025, Guizhou Province, China. 592153968@qq.com
Key Words Hepatocytes; Reticulophagy; Family with sequence similarity 134 member B; Apoptosis; Endoplasmic reticulum stress; Endoplasmic reticulum homeostasis
Core Tip We show that family with sequence similarity 134 member B (FAM134B)-mediated reticulophagy maintains the endoplasmic reticulum (ER) homeostasis in ER-stressed hepatocytes via the clearance of damaged ER fragments. Thereby FAM134B-mediated reticulophagy ameliorates dithiothreitol-induced hepatocyte apoptosis. Our findings provide emerging evidence of the prominence of ER-phagy in ER stress-related hepatocyte apoptosis. FAM134B may represent a potential therapeutic target for liver disease treatment.
Publish Date 2022-06-16 13:07
Citation Guo YX, Han B, Yang T, Chen YS, Yang Y, Li JY, Yang Q, Xie RJ. Family with sequence similarity 134 member B-mediated reticulophagy ameliorates hepatocyte apoptosis induced by dithiothreitol. World J Gastroenterol 2022; 28(23): 2569-2581
URL https://www.wjgnet.com/1007-9327/full/v28/i23/2569.htm
DOI https://dx.doi.org/10.3748/wjg.v28.i23.2569
Full Article (PDF) WJG-28-2569.pdf
Full Article (Word) WJG-28-2569.docx
Manuscript File 74751_Auto_Edited.docx
Answering Reviewers 74751-Answering reviewers.pdf
Audio Core Tip 74751-Audio core tip.mp3
Biostatistics Review Certificate 74751-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 74751-Conflict-of-interest statement.pdf
Copyright License Agreement 74751-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 74751-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 74751-Language certificate.pdf
Supplementary Material 74751-Supplementary material.pptx
Peer-review Report 74751-Peer-review(s).pdf
Scientific Misconduct Check 74751-Bing-Fan JR-2.png
Scientific Editor Work List 74751-Scientific editor work list.pdf