Publication Name	World Journal of Gastroenterology
Manuscript ID	74822
Country	China

Received	2022-01-08 03:31
Peer-Review Started	2022-01-08 03:32
To Make the First Decision
Return for Revision	2022-03-09 04:48
Revised	2022-03-19 08:20
Second Decision	2022-04-22 02:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-04-22 19:03
Articles in Press	2022-04-22 19:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-05-26 06:28
Publish the Manuscript Online	2022-06-02 12:11

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Case Control Study
Article Title	Intermittent hypoxia is involved in gut microbial dysbiosis in type 2 diabetes mellitus and obstructive sleep apnea-hypopnea syndrome
Manuscript Source	Unsolicited Manuscript
All Author List	Sha-Sha Tang, Cheng-Hong Liang, Ya-Lei Liu, Wei Wei, Xin-Ru Deng, Xiao-Yang Shi, Li-Min Wang, Li-Jun Zhang and Hui-Juan Yuan
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81970705 Central Plains Thousand Talents Plan 204200510026
Corresponding Author	Hui-Juan Yuan, PhD, Chief Doctor, Department of Endocrinology, Henan Provincial Key Medicine Laboratory of Intestinal Microecology and Diabetes, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, No. 7 Weiwu Road, Zhengzhou 450003, Henan Province, China. hjyuan@zzu.edu.cn
Key Words	Gut microbiota; Obstructive sleep apnea-hypopnea syndrome; Type 2 diabetes mellitus; Intermittent hypoxia; Obstructive sleep apnea
Core Tip	Clinically, type 2 diabetes mellitus (T2DM) patients have a significantly higher prevalence of obstructive sleep apnea-hypopnea syndrome (OSAHS) than non-T2DM patients and are more prone to diabetes-related complications and metabolic syndrome, including obesity and hypertension. In recent years, the imbalance of gut microbiota has been found to be associated with various metabolic disorders. This study revealed that intermittent hypoxia was associated with changes in the gut microbiota in patients with T2DM complicated by OSAHS. These changes may be involved in the progression of metabolic disorders through increased proinflammatory factors and impaired intestinal barrier function.
Publish Date	2022-06-02 12:11
Citation	Tang SS, Liang CH, Liu YL, Wei W, Deng XR, Shi XY, Wang LM, Zhang LJ, Yuan HJ. Intermittent hypoxia is involved in gut microbial dysbiosis in type 2 diabetes mellitus and obstructive sleep apnea-hypopnea syndrome. World J Gastroenterol 2022; 28(21): 2320-2333
URL	https://www.wjgnet.com/1007-9327/full/v28/i21/2320.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i21.2320

Full Article (PDF)	WJG-28-2320.pdf
Full Article (Word)	WJG-28-2320.docx
STROBE Statement	74822-STROBE-Statement-revision.pdf
Manuscript File	74822_Auto_Edited-LS.docx
Answering Reviewers	74822-Answering reviewers.pdf
Audio Core Tip	74822-Audio core tip.mp3
Biostatistics Review Certificate	74822-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	74822-Conflict-of-interest statement.pdf
Copyright License Agreement	74822-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	74822-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	74822-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	74822-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	74822-Language certificate.pdf
Supplementary Material	74822-Supplementary material.pdf
Peer-review Report	74822-Peer-review(s).pdf
Scientific Misconduct Check	74822-Bing-Fan JR-2.png
Scientific Editor Work List	74822-Scientific editor work list.pdf