Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	74829
Country	Japan

Received	2022-01-08 06:44
Peer-Review Started	2022-01-08 06:46
To Make the First Decision
Return for Revision	2022-03-11 02:00
Revised	2022-03-21 07:51
Second Decision	2022-05-13 02:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-05-14 08:16
Articles in Press	2022-05-14 08:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-05-16 03:45
Publish the Manuscript Online	2022-05-18 11:24

ISSN	2150-5330 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Utility of FibroScan-based scoring systems to narrow the risk group of nonalcoholic fatty liver disease with comorbidities
Manuscript Source	Invited Manuscript
All Author List	Kouichi Miura, Hiroshi Maeda, Naoki Morimoto, Shunji Watanabe, Mamiko Tsukui, Yoshinari Takaoka, Hiroaki Nomoto, Rie Goka, Kazuhiko Kotani and Hironori Yamamoto
Funding Agency and Grant Number
Corresponding Author	Kouichi Miura, Doctor, Associate Professor, Department of Medicine, Jichi Medical University School of Medicine, Jichi Medical University School of Medicine, 3311-1 Yakushiji, , Shimotsuke 329-0498, Tochigi, Japan. miura385@jichi.ac.jp
Key Words	Nonalcoholic fatty liver disease; Vibration controlled transient elastography; Non-invasive test; Hepatocellular carcinoma; Varix
Core Tip	It is necessary to narrow the high-risk group of nonalcoholic fatty liver disease (NAFLD) patients with comorbidities, including hepatocellular carcinoma (HCC) and esophagogastric varices (EGV). Although the fibrosis-4 index is an excellent formula to narrow the high-risk group, there remain many patients to be ruled out. Vibration controlled transient elastography (VCTE) is proposed as a second step examination. FibroScan-AST, Agile 3+, and Agile 4 emerged as VCTE-based scoring systems to determine the status of patients with NAFLD. Here, we demonstrated that Agile 3+ and Agile 4 are good tools to narrow the high-risk group of patients with HCC and/or EGV.
Publish Date	2022-05-18 11:24
Citation	Miura K, Maeda H, Morimoto N, Watanabe S, Tsukui M, Takaoka Y, Nomoto H, Goka R, Kotani K, Yamamoto H. Utility of FibroScan-based scoring systems to narrow the risk group of nonalcoholic fatty liver disease with comorbidities. World J Gastrointest Pathophysiol 2022;13(3): 96-106
URL	https://www.wjgnet.com/2150-5330/full/v13/i3/96.htm
DOI	https://dx.doi.org/10.4291/wjgp.v13.i3.96

Full Article (PDF)	WJGP-13-96.pdf
Full Article (Word)	WJGP-13-96.docx
Manuscript File	74829_Auto_Edited-LJH-LS.docx
Answering Reviewers	74829-Answering reviewers.pdf
Audio Core Tip	74829-Audio core tip.mp3
Biostatistics Review Certificate	74829-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	74829-Conflict-of-interest statement.pdf
Copyright License Agreement	74829-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document	74829-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	74829-Language certificate.pdf
Supplementary Material	74829-Supplementary material.pdf
Peer-review Report	74829-Peer-review(s).pdf
Scientific Misconduct Check	74829-Bing-Liu JH-2.jpg
Scientific Misconduct Check	74829-CrossCheck.jpg
Scientific Editor Work List	74829-Scientific editor work list.pdf