| ISSN |
2150-5330 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Case Control Study |
| Article Title |
Common polymorphisms of protein tyrosine phosphate non-receptor type 2 gene are not associated with risk of Crohn’s disease in Indian
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Kaushik Chatterjee, Amit Kumar Dutta, Ashish Goel, Rekha Aaron, Vijayalekshmi Balakrishnan, Ajith Thomas, Anoop John, Rajeeb Jaleel, Deepu David, Reuben Thomas Kurien, SD Chowdhury, Ebby George Simon, AJ Joseph, Prasanna Premkumar and Anna B Pulimood |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| CMC Vellore FLUID grant |
10360 |
|
| Corresponding Author |
Amit Kumar Dutta, MD, Professor, Department of Gastrointestinal Sciences, Christian Medical College and Hospital, Ground Floor, Williams Building, Vellore 632004, Tamil Nadu, India. akdutta1995@yahoo.co.in |
| Key Words |
PTPN2 gene; Crohn’s disease; Genetic polymorphism; Case-control study; Asia; Risk factor |
| Core Tip |
Several genetic risk factors have been associated with Crohn’s disease and they have provided valuable insights into the pathogenesis of the disease. However, some of the genetic changes are not observed uniformly across all populations and hence it is essential to determine their occurrence in different population. In this prospective case-control study, we have investigated the association of two common polymorphisms in PTPN2 gene (rs7234029 and rs2542151) with risk of Crohn’s Disease in an Asian country. Our results showed that contrary to observation form West, polymorphisms in PTPN2 gene were not associated with an increased risk of developing Crohn’s disease. |
| Publish Date |
2022-07-18 09:11 |
| Citation |
Chatterjee K, Dutta AK, Goel A, Aaron R, Balakrishnan V, Thomas A, John A, Jaleel R, David D, Kurien RT, Chowdhury S, Simon EG, Joseph A, Premkumar P, Pulimood AB. Common polymorphisms of protein tyrosine phosphate non-receptor type 2 gene are not associated with risk of Crohn’s disease in Indian. World J Gastrointest Pathophysiol 2022;13(4): 114-123 |
| URL |
https://www.wjgnet.com/2150-5330/full/v13/i4/114.htm |
| DOI |
https://dx.doi.org/10.4291/wjgp.v13.i4.114 |
