| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Prevalence and clinical characteristics of autoimmune liver disease in hospitalized patients with cirrhosis and acute decompensation in China
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zi-Xuan Shen, Dan-Dan Wu, Jie Xia, Xian-Bo Wang, Xin Zheng, Yan Huang, Bei-Ling Li, Zhong-Ji Meng, Yan-Hang Gao, Zhi-Ping Qian, Feng Liu, Xiao-Bo Lu, Jia Shang, Hua-Dong Yan, Yu-Bao Zheng, Wen-Yi Gu, Yan Zhang, Jian-Yi Wei, Wen-Ting Tan, Yi-Xin Hou, Qun Zhang, Yan Xiong, Cong-Cong Zou, Jun Chen, Ze-Bing Huang, Xiu-Hua Jiang, Sen Luo, Yuan-Yuan Chen, Na Gao, Chun-Yan Liu, Wei Yuan, Xue Mei, Jing Li, Tao Li, Xin-Yi Zhou, Guo-Hong Deng, Jin-Jun Chen, Xiong Ma and Hai Li |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shanghai Hospital Development Commission |
SHDC2020CR1037B |
| National Key R&D Program of China |
2017YFC0908100 |
| National Science and Technology Major Project |
2018ZX10302206, 2018ZX10723203, 2017ZX10202202 |
| Shanghai Municipal Education Commission-Guofeng Clinical Medicine Grant |
20152213 |
| Chongqing Natural Science Foundation |
CSTC2019jcyj-zdxmX0004 |
| National Natural Science Foundation of China |
82170629, 81930061, 81900579, 81970550, 82070613 |
| National Natural Science Foundation of China |
82070650, 81972265 |
| Beijing Municipal Science & Technology Commission |
Z191100006619033 |
| Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program |
2017BT01S131 |
| Foundation for Innovative Research Groups of Hubei Provincial Natural Science Foundation |
2018CFA031 |
| Guangdong Basic and Applied Basic Research Foundation |
2020A1515010052 |
|
| Corresponding Author |
Hai Li, MD, Professor, Department of Gastroenterology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, No. 1630 Dongfang Road, Shanghai 200127, China. hai_17@126.com |
| Key Words |
Prevalence; Autoimmune liver disease; Cirrhosis and acute decompensation; Mortality; Acute-on-chronic liver failure |
| Core Tip |
Autoimmune liver disease (AILD) has been regarded as a relatively rare disease in China. Our study reported that the overall prevalence of AILD was 9.3% hospitalized patients with cirrhosis and acute decompensation, among which primary biliary cirrhosis was the most prevalent type. In AILD patients with cirrhosis and acute decompensation, the etiology types of AILD had no significant effect on short-term mortality, total bilirubin, hepatic encephalopathy (HE) and blood urea nitrogen were independently associated with 90-d mortality in multivariate analysis. Strategies are needed to prevent presence of HE and closely monitor the changes of liver and renal function in clinical practice. These data will be a crucial complement to the public epidemiology research on AILD in Asian-Pacific regions. |
| Publish Date |
2022-08-16 11:59 |
| Citation |
Shen ZX, Wu DD, Xia J, Wang XB, Zheng X, Huang Y, Li BL, Meng ZJ, Gao YH, Qian ZP, Liu F, Lu XB, Shang J, Yan HD, Zheng YB, Gu WY, Zhang Y, Wei JY, Tan WT, Hou YX, Zhang Q, Xiong Y, Zou CC, Chen J, Huang ZB, Jiang XH, Luo S, Chen YY, Gao N, Liu CY, Yuan W, Mei X, Li J, Li T, Zhou XY, Deng GH, Chen JJ, Ma X, Li H. Prevalence and clinical characteristics of autoimmune liver disease in hospitalized patients with cirrhosis and acute decompensation in China. World J Gastroenterol 2022;28(31): 4417-4430 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i31/4417.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i31.4417 |
