Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	76336
Country	United Arab Emirates

Received	2022-03-16 00:22
Peer-Review Started	2022-03-16 00:24
To Make the First Decision
Return for Revision	2022-04-17 03:22
Revised	2022-05-05 16:06
Second Decision	2022-07-21 03:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-07-26 19:06
Articles in Press	2022-07-26 19:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-08-26 01:30
Publish the Manuscript Online	2022-09-09 12:48

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Review
Article Title	Emerging role of caldesmon in cancer: A potential biomarker for colorectal cancer and other cancers
Manuscript Source	Invited Manuscript
All Author List	Alya R Alnuaimi, Vidhya A Nair, Lara J Bou Malhab, Eman Abu-Gharbieh, Anu Vinod Ranade, Gianfranco Pintus, Mohamad Hamad, Hauke Busch, Jutta Kirfel, Rifat Hamoudi and Wael M Abdel-Rahman
Funding Agency and Grant Number
Corresponding Author	Wael M Abdel-Rahman, MD, PhD, Professor, Department of Medical Laboratory Sciences, University of Sharjah, University City, Sharjah 27272, United Arab Emirates. whassan@sharjah.ac.ae
Key Words	Bladder cancer; CALD1; Caldesmon; Chemoresistance; Colorectal cancer; Gastric cancer; Glioma; Epithelial to mesenchymal transition; Invasion; Metastasis
Core Tip	The actin-binding protein caldesmon (CaD) plays an important role in cancer development, metastasis, and resistance to chemotherapy. CaD has emerged as a significant player in carcinogenesis, as it features many cancer hallmarks, including epithelial mesenchymal transition, angiogenesis, and immune evasion. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues. These data qualify CaD as an attractive candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer.
Publish Date	2022-09-09 12:48
Citation	Alnuaimi AR, Nair VA, Malhab LJB, Abu-Gharbieh E, Ranade AV, Pintus G, Hamad M, Busch H, Kirfel J, Hamoudi R, Abdel-Rahman WM. Emerging role of caldesmon in cancer: A potential biomarker for colorectal cancer and other cancers. World J Gastrointest Oncol 2022; 14(9): 1637-1653
URL	https://www.wjgnet.com/1948-5204/full/v14/i9/1637.htm
DOI	https://dx.doi.org/10.4251/wjgo.v14.i9.1637

Full Article (PDF)	WJGO-14-1637.pdf
Full Article (Word)	WJGO-14-1637.docx
Manuscript File	76336_Author_Edited-LM.docx
Answering Reviewers	76336-Answering reviewers.pdf
Audio Core Tip	76336-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	76336-Conflict-of-interest statement.pdf
Copyright License Agreement	76336-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	76336-Language certificate.pdf
Supplementary Material	76336-Supplementary material.pdf
Peer-review Report	76336-Peer-review(s).pdf
Scientific Misconduct Check	76336-Bing-Wang JJ-2.png
Scientific Editor Work List	76336-Scientific editor work list.pdf