Publication Name	World Journal of Clinical Oncology
Manuscript ID	76675
Country	China

Received	2022-03-28 10:51
Peer-Review Started	2022-03-28 10:53
To Make the First Decision
Return for Revision	2022-06-23 12:04
Revised	2022-06-26 10:24
Second Decision	2022-09-09 03:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-09-12 17:54
Articles in Press	2022-09-12 17:54
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-09-07 13:29
Typeset the Manuscript	2022-09-14 06:39
Publish the Manuscript Online	2022-09-22 06:32

ISSN	2218-4333 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Minireviews
Article Title	Hyperprogression under treatment with immune-checkpoint inhibitors in patients with gastrointestinal cancer: A natural process of advanced tumor progression?
Manuscript Source	Invited Manuscript
All Author List	Mo-Xuan Wang, Shu-Yue Gao, Fan Yang, Run-Jia Fan, Qin-Na Yang, Tian-Lan Zhang, Nian-Song Qian and Guang-Hai Dai
Funding Agency and Grant Number
Corresponding Author	Nian-Song Qian, PhD, Associate Professor, Department of Oncology, Senior Department of Respiratory and Critical Care Medicine, The Eighth Medical Center of Chinese PLA General Hospital, No.17 A Heishanhu Road, Haidian District, Beijing 100853, China. kyotomed@foxmail.com
Key Words	Wang MX, Gao SY, Yang F, Fan RJ, Yang QN, Zhang TL, Qian NS, Dai GH. Hyperprogression under treatment with immune-checkpoint inhibitors in patients with gastrointestinal cancer: A natural process of advanced tumor progression? World J Clin Oncol 2022; In press
Core Tip	Several literature reviews exist on the definition, incidence, predictors, potential biomarkers and prognosis for HPD. However, this is a mini review of two contending viewpoints: HPD as a new form of immunological response vs. natural advanced tumor progression. It also takes a look at cellular and molecular mechanisms of the pathways of tumor microenvironment and recent clinical trials exploring the risk factors and mechanisms of HPD in gastrointestinal cancer.
Publish Date	2022-09-22 06:32
Citation	Wang MX, Gao SY, Yang F, Fan RJ, Yang QN, Zhang TL, Qian NS, Dai GH. Hyperprogression under treatment with immune-checkpoint inhibitors in patients with gastrointestinal cancer: A natural process of advanced tumor progression? World J Clin Oncol 2022; 13(9): 729-737
URL	https://www.wjgnet.com/2218-4333/full/v13/i9/729.htm
DOI	https://dx.doi.org/10.5306/wjco.v13.i9.729

Full Article (PDF)	WJCO-13-729.pdf
Full Article (Word)	WJCO-13-729.docx
Manuscript File	76675_Auto_Edited-LLW-WangTQ-LS.docx
Answering Reviewers	76675-Answering reviewers.pdf
Audio Core Tip	76675-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	76675-Conflict-of-interest statement.pdf
Copyright License Agreement	76675-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	76675-Language certificate.pdf
Peer-review Report	76675-Peer-review(s).pdf
Scientific Misconduct Check	76675-Bing-Wang LL-2.png
Scientific Editor Work List	76675-Scientific editor work list.pdf
CrossCheck Report	76675-CrossCheck report.pdf