Publication Name	World Journal of Gastroenterology
Manuscript ID	7877
Country	Italy

Received	2013-12-04 09:01
Peer-Review Started	2013-12-04 11:36
To Make the First Decision	2014-01-24 12:39
Return for Revision	2014-01-25 14:53
Revised	2014-02-10 15:49
Second Decision	2014-05-05 08:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-05-05 09:49
Articles in Press	2014-05-23 09:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-26 09:45
Publish the Manuscript Online	2014-09-18 19:50

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Proteinase activated-receptors-associated signaling in the control of gastric cancer
Manuscript Source	Invited Manuscript
All Author List	Silvia Sedda, Irene Marafini, Roberta Caruso, Francesco Pallone and Giovanni Monteleone
Funding Agency and Grant Number
Corresponding Author	Giovanni Monteleone, MD, PhD, Dipartimento di Medicina dei Sistemi, Università Tor Vergata, Via Montpellier 1, 00133 Rome, Italy. gi.monteleone@med.uniroma2.it
Key Words	Proteinase activated-receptors; gastric cancer; Helicobacter pylori; infection
Core Tip	In recent years, a large body of evidence has been accumulated to support the role of proteinase activated-receptors (PARs) in the control of gastric cancer (GC). In particular, it has been demonstrated that both PAR-1 and PAR-2 may trigger intracellular signals which ultimately sustain gastric carcinogenesis, whereas the exact role of PAR-3 and PAR-4 in the initiation and progression of GC remains to be ascertained. Despite these promising and novel observations, further experimentation is needed to better characterize the mechanisms underlying the expression and function of PARs in GC and their potential as therapeutic targets.
Publish Date	2014-09-18 19:50
Citation	Sedda S, Marafini I, Caruso R, Pallone F, Monteleone G. Proteinase activated-receptors-associated signaling in the control of gastric cancer. World J Gastroenterol 2014; 20(34): 11977-11984
URL	http://www.wjgnet.com/1007-9327/full/v20/i34/11977.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i34.11977

Full Article (PDF)	WJG-20-11977.pdf
Full Article (Word)	WJG-20-11977.doc
Manuscript File	7877-Review.docx
Answering Reviewers	7877-Answering reviewers.pdf
Copyright License Agreement	7877-Copyright assignment.PDF
Peer-review Report	7877-Peer review(s).pdf
Scientific Editor Work List	7877-Scientific editor work list.pdf