Publication Name	World Journal of Gastroenterology
Manuscript ID	80199
Country	Chile

Received	2022-09-20 01:07
Peer-Review Started	2022-09-20 01:09
To Make the First Decision
Return for Revision	2022-10-20 06:04
Revised	2022-11-07 21:56
Second Decision	2023-02-24 03:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2023-03-13 16:24
Articles in Press	2023-03-13 16:24
Publication Fee Transferred
Edit the Manuscript by Language Editor	2023-03-21 02:09
Typeset the Manuscript	2023-03-31 02:39
Publish the Manuscript Online	2023-04-14 13:45

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Intersections between innate immune response and gastric cancer development
Manuscript Source	Invited Manuscript
All Author List	Franz Villarroel-Espindola, Troy Ejsmentewicz, Roxana Gonzalez-Stegmaier, Roddy A Jorquera and Esteban Salinas
Funding Agency and Grant Number	Funding Agency Grant Number National Research and Development Agency of Chile (ANID) and National Fund for Scientific and Technological Development (FONDECYT) 1221415 Instituto Oncológico Fundación Arturo López Pérez, Santiago, Chile
Corresponding Author	Franz Villarroel-Espindola, PhD, Director, Director, Translational Medicine Unit, Instituto Oncologico Fundacion Arturo Lopez Perez, Rancagua 878, Providencia, Santiago 7500000, Metropolitan Region, Chile. franz.villarroel@falp.org
Key Words	Gastric cancer; Toll-like receptor; Helicobacter pylori; Nuclear factor kappa B; Neutrophils
Core Tip	Premalignant cascade of gastric cancer starts with a chronic gastritis, and evolves to atrophic gastritis, intestinal metaplasia, dysplasia and finally the carcinoma. During the process, different immune responses contribute to inflammation of the gastric epithelium. Our work compiles studies related to the innate immune response with a focus on molecular and cellular features such as, Toll-like receptors, neutrophils, cytokines and socioeconomic factors, as crucial players during the precancerous cascade and the cancer onset.
Publish Date	2023-04-14 13:45
Citation	Villarroel-Espindola F, Ejsmentewicz T, Gonzalez-Stegmaier R, Jorquera RA, Salinas E. Intersections between innate immune response and gastric cancer development. World J Gastroenterol 2023; 29(15): 2222-2240
URL	https://www.wjgnet.com/1007-9327/full/v29/i15/2222.htm
DOI	https://dx.doi.org/10.3748/wjg.v29.i15.2222

Full Article (PDF)	WJG-29-2222.pdf
Full Article (Word)	WJG-29-2222.docx
Manuscript File	80199-Review-Filipodia.docx
Answering Reviewers	80199-Answering reviewers.pdf
Audio Core Tip	80199-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	80199-Conflict-of-interest statement.pdf
Copyright License Agreement	80199-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	80199-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	80199-Language certificate.pdf
Peer-review Report	80199-Peer-review(s).pdf
Scientific Editor Work List	80199-Scientific editor work list.pdf
CrossCheck Report	80199-CrossCheck report.pdf